A-72363 A-1、A-2和C，来自诺尔斯链霉菌SANK 60192的新型乙酰肝素酶抑制剂。I. 产生菌的分类学、发酵、分离及结构解析

A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation.

作者信息

Takatsu T, Takahashi M, Kawase Y, Enokita R, Okazaki T, Matsukawa H, Ogawa K, Sakaida Y, Kagasaki T, Kinoshita T, Nakajima M, Tanzawa K

机构信息

Biomedical Research Laboratories, Sankyo Co., Ltd, Tokyo 140, Japan.

出版信息

J Antibiot (Tokyo). 1996 Jan;49(1):54-60. doi: 10.7164/antibiotics.49.54.

DOI:10.7164/antibiotics.49.54

PMID:8609086

Abstract

Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.

摘要

新型乙酰肝素酶抑制剂A72363 A-1、A-2和C，是从诺尔斯链霉菌SANK 60192的培养滤液中，通过在各种树脂吸附剂上进行柱色谱分离，然后进行制备型阴离子交换高效液相色谱法分离得到的。光谱研究表明，它们是神经氨酸酶抑制剂西他司丁B的非对映异构体。