曲霉酸，一种由短柄曲霉产生的新型代谢产物，可抑制肿瘤细胞乙酰肝素酶：产生菌株的分类学、发酵、分离、结构解析及生物活性

Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity.

作者信息

Shiozawa H, Takahashi M, Takatsu T, Kinoshita T, Tanzawa K, Hosoya T, Furuya K, Takahashi S, Furihata K, Seto H

机构信息

Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1995 May;48(5):357-62. doi: 10.7164/antibiotics.48.357.

DOI:10.7164/antibiotics.48.357

PMID:7797435

Abstract

Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 microM.

摘要

从曲霉菌Talaromyces trachyspermus SANK 12191的培养液中分离出一种新的代谢产物——曲霉菌酸，它能够抑制乙酰肝素酶。通过核磁共振光谱分析和化学反应推断其结构为一种含有螺缩酮的三羧酸衍生物。曲霉菌酸对乙酰肝素酶的IC50值为36微摩尔。