Pentney P T, Bubenik G A
Department of Zoology, University of Guelph, Ontario, Canada.
J Pineal Res. 1995 Aug;19(1):31-9. doi: 10.1111/j.1600-079x.1995.tb00168.x.
Melatonin administration reduces the severity of dextran sodium sulphate (DSS)-induced colitis in mice. After 7 weeks of daily intraperitoneal melatonin administration (150 micrograms/kg), rectal bleeding and occult blood was eliminated in all mice in which colitis was induced by DSS. In addition the frequency and severity of focal lesions in the mucosa was dramatically reduced. Furthermore, weight loss and higher food consumption observed in DSS-treated mice was reversed in DSS-treated mice injected with melatonin. All treated groups exhibited significant alterations in goblet cell distribution as a result of DSS or melatonin administration. Surprisingly, serum melatonin levels were more than 10 times higher in mice that received DSS as compared to controls. The significant improvement in the conditions of melatonin-treated mice might be due to its effect on the smooth muscles of the colon, the blood supply in the mucosa, its capability as an antioxidant and scavenger of free radicals, or its effect on the immune system of the gut. The higher plasma levels of melatonin in DSS-treated mice might be due to a stress-induced increase in the production of gastrointestinal (GIT) melatonin.
褪黑素给药可减轻硫酸葡聚糖钠（DSS）诱导的小鼠结肠炎的严重程度。在每天腹腔注射褪黑素（150微克/千克）7周后，所有由DSS诱导结肠炎的小鼠的直肠出血和潜血均消失。此外，黏膜局灶性病变的频率和严重程度显著降低。此外，在注射褪黑素的DSS处理小鼠中，DSS处理小鼠中观察到的体重减轻和更高的食物消耗量得到了逆转。由于给予DSS或褪黑素，所有处理组的杯状细胞分布均出现显著改变。令人惊讶的是，与对照组相比，接受DSS的小鼠血清褪黑素水平高出10倍以上。褪黑素处理小鼠状况的显著改善可能归因于其对结肠平滑肌、黏膜血液供应的影响，其作为抗氧化剂和自由基清除剂的能力，或其对肠道免疫系统的影响。DSS处理小鼠中较高的血浆褪黑素水平可能是由于应激诱导胃肠道（GIT）褪黑素产生增加所致。
