Antiszko M, Braczko M, Grzybowski J, Jethon J
Zakład Mikrobiologii, Wojskowy Instytut Higieny i Epidemiologii, Warszawie.
Polim Med. 1995;25(3-4):37-45.
The results of haemostatic properties examination of bovine collagen membranes and sponges manufactured in Poland in comparison to Spongostan are presented. In the first step of investigation the experiments were performed using punctured mouse livers. The second step comprised clinical trials in seven patients hospitalised in the Department of Plastic Surgery. The estimated parameter was the time of parenchymal bleeding from punctured livers of from donor places after cutting of the skin for split thickness grafts. The application of tested collagenic membranes or sponges caused effective decreasing of bleeding time. They are potent agents in the cases of abundant capillary bleeding of parenchymal organs and cutaneous tissues. The efficacy of hemostasis initiated by collagen membranes was the same as for Spongostan. The highest haemostatic potency possessed collagenic sponge.
本文展示了波兰生产的牛胶原蛋白膜和海绵与Spongostan相比的止血性能检测结果。在研究的第一步，实验采用穿刺小鼠肝脏进行。第二步包括对整形外科住院的7名患者进行临床试验。评估参数为穿刺肝脏实质出血时间或切取中厚皮片供区皮肤后出血时间。应用测试的胶原蛋白膜或海绵可有效缩短出血时间。它们在实质器官和皮肤组织大量毛细血管出血的情况下是有效的止血剂。胶原蛋白膜引发的止血效果与Spongostan相同。胶原蛋白海绵具有最高的止血效力。
