Duvernoy O, Malm T, Ramström J, Bowald S
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Thorac Cardiovasc Surg. 1995 Oct;43(5):271-4. doi: 10.1055/s-2007-1013226.
Biodegradable patches made of polyhydroxybutyrate (PHB) were recently shown to limit postoperative pericardial adhesions when inserted into the pericardium in sheep. The present study was carried out to evaluate the presence of post-operative retrosternal adhesions after cardiac surgery in patients operated on with the PHB patch compared with those operated on without the insertion of such a patch. 50 patients admitted for CABG and/or valvular replacement were randomised to treatment either with pericardial closure with a patch or with the pericardium left open. In 39 of these (19 with and 20 without a PHB patch) computerised tomography was carried out six and twenty-four months postoperatively. Computerised tomography indicated a lower incidence (p < 0.05) of postoperative adhesions between the patch and the cardiac surface in the patch group, compared with the corresponding area in the non-patch group. A reduction of patch size in 27% (p = 0.003) was also seen.
最近有研究表明，由聚羟基丁酸酯（PHB）制成的可生物降解贴片在植入绵羊心包后，可限制术后心包粘连。本研究旨在评估与未植入此类贴片的患者相比，接受心脏手术时使用PHB贴片的患者术后胸骨后粘连的情况。50例因冠状动脉旁路移植术（CABG）和/或瓣膜置换术入院的患者被随机分为两组，一组采用贴片心包闭合术，另一组心包敞开。其中39例患者（19例使用PHB贴片，20例未使用）在术后6个月和24个月进行了计算机断层扫描。计算机断层扫描显示，与未使用贴片组的相应区域相比，贴片组中贴片与心脏表面之间术后粘连的发生率较低（p < 0.05）。此外，还观察到贴片尺寸减小了27%（p = 0.003）。
