Fogelholm R, Murros K, Rissanen A, Ilmavirta M
Department of Neurology, Central Hospital of Central Finland.
Stroke. 1996 Mar;27(3):398-400. doi: 10.1161/01.str.27.3.398.
Clinical trials of new drugs that reverse neurological deficits when used in the first hours of stroke onset suggest that early hospital admission is important. We analyzed a database of patients with acute stroke to determine the factors that delay hospital admission.
We analyzed all patients with their first stroke during 1993 in the province of Central Finland (population, 256 000). Patients referred to the Central Hospital, the only tertiary referral hospital in the area, were included in the study.
Of the patients with first stroke, 363 (79%) were admitted to the Central Hospital. The stroke subtype was confirmed in 356 (98%) patients with CT scan, and the patient population included 272 (75%) with brain infarction, 51 (14%) with intracerebral hemorrhage, and 40 (11%) with subarachnoid hemorrhage. The most important factor associated with a delay in reaching the hospital was the referral pattern. The median delay was 2 hours for patients brought directly to the Central Hospital, 8 hours if a physician at the local health center was consulted, and 47 hours if the patient was first admitted to the health center for observation. Other factors associated with a delay were ischemic stroke and stroke onset in the evening or night or during the weekend.
The majority of patients who are candidates for acute stroke trials arrive at the hospital after prolonged delays for multiple reasons. Public and medical personnel education could result in signficant reduction in these delays.
在卒中发作后的最初数小时内使用可逆转神经功能缺损的新药进行的临床试验表明,早期入院治疗很重要。我们分析了急性卒中患者数据库,以确定延迟入院的因素。
我们分析了1993年芬兰中部省份(人口25.6万)首次发生卒中的所有患者。被转诊至该地区唯一的三级转诊医院——中心医院的患者纳入本研究。
在首次发生卒中的患者中,363例(79%)被收治入中心医院。356例(98%)患者通过CT扫描确诊了卒中亚型,患者群体包括272例(75%)脑梗死患者、51例(14%)脑出血患者和40例(11%)蛛网膜下腔出血患者。与延迟到达医院相关的最重要因素是转诊模式。直接送至中心医院的患者中位延迟时间为2小时;若咨询当地卫生中心的医生,延迟时间为8小时;若患者首先入住卫生中心进行观察,延迟时间为47小时。与延迟相关的其他因素包括缺血性卒中和卒中在傍晚、夜间或周末发作。
大多数有资格参加急性卒中试验的患者因多种原因在长时间延迟后才到达医院。对公众和医务人员进行教育可显著减少这些延迟。