Volavka J, Czobor P, Goodwin D W, Gabrielli W F, Penick E C, Mednick S A, Jensen P, Knop J
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Arch Gen Psychiatry. 1996 Mar;53(3):258-63. doi: 10.1001/archpsyc.1996.01830030080012.
In 1979 through 1980, electroencephalographic (EEG) responses to an alcohol challenge in 19 year-old sons of alcoholics as well as in sons of nonalcoholic control subjects were examined. The familial risk status of the subjects and greater EEG sensitivity to alcohol were hypothesized to predict the development of alcoholism 10 years later.
In 1990 through 1992, diagnostic interviews were completed to ascertain alcohol and other substance use disorders in these subjects and to update their family history.
Updated family history of alcoholism predicted the development of substance dependence. Density of alcoholic relatives (the number of alcoholic relatives divided by the number of known relatives) was positively related to the severity of alcohol use disorders in the probands. Contrary to expectation, a greater EEG response at age 19 years was not related to the later development of alcohol dependence. Instead, the opposite was observed: a smaller EEG alpha frequency response to alcohol at age 19 years was related to the development of alcohol dependence and high quantity and frequency of alcohol consumption 10 years later.
Lower EEG response to a small dose of alcohol may be associated with the later development of alcohol dependence. This result is based on a small number of subjects and should be interpreted with caution. Although this result is opposite to our 1980 hypothesis, it is consistent with much of the recent literature.
在1979年至1980年期间，对酗酒者的19岁儿子以及非酗酒对照对象的儿子进行了脑电图（EEG）对酒精激发试验的反应检查。假设受试者的家族风险状况以及对酒精更高的脑电图敏感性可预测10年后酒精中毒的发生。
在1990年至1992年期间，完成了诊断访谈，以确定这些受试者的酒精及其他物质使用障碍情况，并更新他们的家族史。
更新后的酗酒家族史可预测物质依赖的发生。酗酒亲属密度（酗酒亲属数量除以已知亲属数量）与先证者酒精使用障碍的严重程度呈正相关。与预期相反，19岁时更大的脑电图反应与后来酒精依赖的发展无关。相反，观察到的情况是：19岁时对酒精的脑电图α频率反应较小与10年后酒精依赖的发展以及高饮酒量和高饮酒频率有关。
对小剂量酒精的脑电图反应较低可能与后来酒精依赖的发展有关。该结果基于少数受试者，应谨慎解释。尽管这一结果与我们1980年的假设相反，但与最近的许多文献一致。
