Pollock V E, Volavka J, Goodwin D W, Mednick S A, Gabrielli W F, Knop J, Schulsinger F
Arch Gen Psychiatry. 1983 Aug;40(8):857-61. doi: 10.1001/archpsyc.1983.01790070047006.
The biologic sons of alcoholics constitute a group at high risk (HR) for alcoholism. A 0.5-g/kg dose of alcohol was administered to HR and control subjects aged 19 to 21 years. Blood alcohol concentration measurements failed to distinguish HR from control subjects, but quantitative measurements of EEG alpha activity differentiated them. The HR subjects exhibited greater increases in slow alpha energy and greater decreases of fast alpha energy after alcohol administration than controls; the HR subjects also showed greater decreases in mean alpha frequency after alcohol administration. These EEG findings suggest that subjects at high risk for alcoholism are physiologically more sensitive to alcohol than control subjects.
酗酒者的亲生儿子构成了酗酒的高危（HR）群体。对年龄在19至21岁的高危人群和对照受试者给予0.5克/千克剂量的酒精。血液酒精浓度测量未能区分高危人群和对照受试者，但脑电图α活动的定量测量将他们区分开来。与对照组相比，高危人群在饮酒后慢α波能量增加更多，快α波能量减少更多；高危人群在饮酒后平均α波频率也降低更多。这些脑电图研究结果表明，酗酒高危人群在生理上对酒精比对照受试者更敏感。
