Dello Strologo L, Massella L, Rizzoni G
Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital, Institute for Scientific Research, Rome, Italy.
Pediatr Nephrol. 1996 Feb;10(1):81-3. doi: 10.1007/BF00863455.
We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.
我们研究了单次口服环孢素A（CsA）作为免疫抑制方案一部分给予6名青少年肾移植受者后的急性血流动力学效应。通过持续输注菊粉和氨基马尿酸12小时来测定肾血浆流量（RPF）和肾小球滤过率（GFR）。在血浆CsA水平达到峰值后4 - 6小时观察到GFR和RPF均下降。未发现与CsA剂量或任何药代动力学参数有显著相关性。本研究表明，CsA在青少年受者中也具有血管收缩作用；这可能是其肾毒性的原因之一。
