Pees H W
Br J Cancer. 1977 May;35(5):537-45. doi: 10.1038/bjc.1977.87.
Cell-mediated cytotoxicity (CTX) was studied in meningioma patients before and within 2 weeks of complete excision of the tumour, using the [3H]-prolin- microcytotoxicity test. Three of 7 patients tested before surgery showed specific CTX, 2 revealed a "non-specific" (tumour-unrelated) response, and 2 were non-reactive. After surgery, CTX decreased from 84 to 50% in one patient and became negative in 2 others previously positive. One of 2 patients showing "non-specific" CTX preoperatively became positive, while the other remained unchanged. All patients were receiving dexamethasone (DXM) at the time they were tested. Lymphocyte responses to PHA were not significantly different before or after surgery (i.e. after prolonged treatment with DXM), from healthy controls. Blocking activity could be detected in the sera of all 3 patients before surgery. This activity was not specific for meningiomas. Paradoxically, the same sera did not inhibit the proliferative response to PHA. Serum from only one patient consistently suppressed the blastogenic response of homologous lymphocytes to PHA. Inhibitory activity was associated with the IgG fraction of his serum.
采用[3H]-脯氨酸-微量细胞毒性试验，对脑膜瘤患者在肿瘤完全切除术前及术后2周内的细胞介导细胞毒性（CTX）进行了研究。7例术前检测的患者中，3例显示出特异性CTX，2例表现出“非特异性”（与肿瘤无关）反应，2例无反应。术后，1例患者的CTX从84%降至50%，另外2例术前阳性的患者术后变为阴性。术前显示“非特异性”CTX的2例患者中，1例变为阳性，另1例保持不变。所有患者在检测时均接受地塞米松（DXM）治疗。术前和术后（即经过长时间DXM治疗后），淋巴细胞对PHA的反应与健康对照相比无显著差异。术前所有3例患者的血清中均可检测到阻断活性。这种活性并非脑膜瘤所特有。矛盾的是，相同的血清并不抑制对PHA的增殖反应。仅1例患者的血清持续抑制同源淋巴细胞对PHA的增殖反应。抑制活性与其血清的IgG组分相关。
