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中枢神经系统肿瘤中的特异性淋巴细胞毒性和阻断因子。

Specific lymphocytotoxicity and blocking factors in tumours of the central nervous system.

作者信息

Kumar S, Taylor G

出版信息

Br J Cancer Suppl. 1973 Aug;1:135-41.

PMID:4804276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149049/
Abstract

The results of lymphocytotoxicity tests, in autologous and allogeneic combinations, on 23 human CNS tumours are presented. The specific lymphocytotoxicity was directed against morphologically distinguishable neoplastic cells and this reactivity was “tumour type” and not “brain tumour specific”. Serum samples from patients with clinically active glial tumours had activity which significantly cancelled the specific cytotoxicity of autologous lymphocytes.

摘要

本文展示了对23例人类中枢神经系统肿瘤进行自体和异体组合淋巴细胞毒性试验的结果。特异性淋巴细胞毒性针对形态上可区分的肿瘤细胞，且这种反应是“肿瘤类型特异性”而非“脑肿瘤特异性”。临床活跃的胶质细胞瘤患者的血清样本具有显著消除自体淋巴细胞特异性细胞毒性的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/deb6b29e8b39/brjcancersuppl00059-0136-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/5294568f7958/brjcancersuppl00059-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/0a9120900d7a/brjcancersuppl00059-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/deb6b29e8b39/brjcancersuppl00059-0136-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/5294568f7958/brjcancersuppl00059-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/0a9120900d7a/brjcancersuppl00059-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/2149049/deb6b29e8b39/brjcancersuppl00059-0136-b.jpg

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Specific lymphocytotoxicity and blocking factors in tumours of the central nervous system.中枢神经系统肿瘤中的特异性淋巴细胞毒性和阻断因子。
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引用本文的文献

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Acta Neurochir (Wien). 1981;55(3-4):181-200. doi: 10.1007/BF01808436.
2
Cell-mediated immune response of patients with meningiomas defined in vitro by a [3H]proline microcytotoxicity test.通过[3H]脯氨酸微细胞毒性试验在体外定义的脑膜瘤患者的细胞介导免疫反应。
Clin Exp Immunol. 1976 May;24(2):310-6.
3
Influence of surgery and dexamethasone on cell-mediated immune responses in patients with meningiomas.

本文引用的文献

1
The transplantation of tumors to the brains of heterologous species.将肿瘤移植到异种动物的大脑中。
Cancer Res. 1951 Jul;11(7):529-34.
2
Immunization against intracerebral transplantation of a glioma in mice.小鼠脑内胶质瘤移植的免疫接种
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3
Response of human blood lymphocytes to tuberculin PPD in tissue culture.人血淋巴细胞在组织培养中对结核菌素纯蛋白衍生物的反应。
手术和地塞米松对脑膜瘤患者细胞介导免疫反应的影响。
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The localization of radioantibodies in human brain tumors. I. Preliminary exploration.
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In vitro studies of immune reactions against autochthonous and syngeneic mouse tumors induced by methylcholanthrene and plastic discs.针对甲基胆蒽和塑料盘诱导的同种和同基因小鼠肿瘤的免疫反应的体外研究。
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Immunological properties of neoplastic neural tissues.
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The concept of immunological surveillance.免疫监视的概念。
Prog Exp Tumor Res. 1970;13:1-27. doi: 10.1159/000386035.
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Immunological properties of normal neural tissues.正常神经组织的免疫学特性。
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9
Development of malignant cerebral lymphoma in a patient with systemic lupus erythematosus treated with immunosuppression.一名接受免疫抑制治疗的系统性红斑狼疮患者发生恶性脑淋巴瘤。
Arthritis Rheum. 1972 Mar-Apr;15(2):183-6. doi: 10.1002/art.1780150207.
10
Cellular immunity in Wilm's tumour and neuroblastoma.肾母细胞瘤和神经母细胞瘤中的细胞免疫
Int J Cancer. 1972 Jul 15;10(1):36-43. doi: 10.1002/ijc.2910100107.