Specific lymphocytotoxicity and blocking factors in tumours of the central nervous system.

The results of lymphocytotoxicity tests, in autologous and allogeneic combinations, on 23 human CNS tumours are presented. The specific lymphocytotoxicity was directed against morphologically distinguishable neoplastic cells and this reactivity was “tumour type” and not “brain tumour specific”. Serum samples from patients with clinically active glial tumours had activity which significantly cancelled the specific cytotoxicity of autologous lymphocytes.