Juneja S K, Matthews J P, Luzinat R, Fan Y, Michael M, Rischin D, Millward M J, Toner G C
Department of Pathology, Peter MacCallum Cancer Institute, Melbourne, Australia.
Br J Haematol. 1996 Apr;93(1):139-41. doi: 10.1046/j.1365-2141.1996.4701020.x.
We describe the occurrence of acquired Pelger-Huet anomaly (APHA) in 23 patients treated with paclitaxel (13) or docetaxel (10). A consistent peak of Pelger-Huet cells (PHC) within a range of 3-9 d after treatment with taxoids was noted. The APHA generally disappeared by day 21 after treatment. Peak PHC values for the first course were significantly different in paclitaxel versus docetaxel versus control groups (P < 0.0001) with the maximum PHC counts being significantly higher for docetaxel compared with paclitaxel (P < 0.001) and for paclitaxel compared with controls (P = 0.007). We conclude that taxoid therapy produces transient APHA which peaks between days 3 and 9 and is more pronounced with docetaxel than with paclitaxel.
我们描述了23例接受紫杉醇（13例）或多西他赛（10例）治疗的患者出现获得性Pelger-Huet异常（APHA）的情况。在用紫杉烷类药物治疗后的3至9天内，观察到Pelger-Huet细胞（PHC）出现一致的峰值。APHA通常在治疗后第21天消失。紫杉醇组、多西他赛组和对照组在首个疗程中的PHC峰值存在显著差异（P < 0.0001），多西他赛组的最大PHC计数显著高于紫杉醇组（P < 0.001），紫杉醇组显著高于对照组（P = 0.007）。我们得出结论，紫杉烷类药物治疗会产生短暂的APHA，其峰值出现在第3至9天，多西他赛比紫杉醇更明显。
