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25-羟基维生素D3 24-羟化的机制：氧-18掺入25-羟基维生素D3的24位。

Mechanism of 25-hydroxyvitamin D3 24-hydroxylation: incorporation of oxygen-18 into the 24 position of 25-hydroxyvitamin D3.

作者信息

Madhok T C, Schnoes H K, DeLuca H F

出版信息

Biochemistry. 1977 May 17;16(10):2142-5. doi: 10.1021/bi00629a015.

DOI:10.1021/bi00629a015
PMID:861200
Abstract

The oxygen enzymatically inserted as a hydroxyl function by chick kidney homogenate into the 24 position of 25-hydroxyvitamin D3 to give 24,25-dihydroxyvitamin D3 is derived exclusively from 18O2. Therefore, like the 25-hydroxyvitamin D3-lalpha-hydroxylase system, the 25-hydroxyvitamin D3-24-hydroxylase system is also a monooxygenase ("mixed-function oxidase").

摘要

鸡肾匀浆通过酶促反应将氧作为羟基功能基团插入到25-羟基维生素D3的24位，生成24,25-二羟基维生素D3，其中的氧完全来自18O2。因此，与25-羟基维生素D3-1α-羟化酶系统一样，25-羟基维生素D3-24-羟化酶系统也是一种单加氧酶（“混合功能氧化酶”）。

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Mechanism of 25-hydroxyvitamin D3 24-hydroxylation: incorporation of oxygen-18 into the 24 position of 25-hydroxyvitamin D3.25-羟基维生素D3 24-羟化的机制：氧-18掺入25-羟基维生素D3的24位。
Biochemistry. 1977 May 17;16(10):2142-5. doi: 10.1021/bi00629a015.
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24-hydroxylation of 25-hydroxyvitamin D3: is it required for embryonic development in chicks?25-羟基维生素D3的24-羟化：它是雏鸡胚胎发育所必需的吗？
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