Batterman J, Mazza D S, Meriney D K, Cleveland W L, Reddy M M, Grieco M H
R.A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital Center, New York, USA.
Ann Allergy Asthma Immunol. 1996 Apr;76(4):359-62. doi: 10.1016/S1081-1206(10)60038-5.
Soluble CD23 is the proteolytic cleavage product of the low affinity receptor (FcERII). Functions of CD23 and its soluble products may include upregulation of IgE production and stimulation of B lymphocyte growth.
Soluble CD23 was quantitated in supernatants of lymphocytes from nine ragweed-sensitive and eight nonatopic subjects stimulated in vitro by antigen E (amb Al), crude ragweed extract, and pokeweed mitogen (PWM).
Although PWM stimulation produced no significant difference between groups, sCD23 release was significantly elevated in the cells of nonatopic patients stimulated with antigen E and crude ragweed extract (P less than .05).
This finding supports the concept of separate pathways of activation by antigen and mitogen for sCD23 release and suggests ragweed-sensitive and nonatopic patients have fundamental differences in the response of sCD23 release to ragweed antigen stimulation.
可溶性CD23是低亲和力受体（FcERII）的蛋白水解裂解产物。CD23及其可溶性产物的功能可能包括上调IgE产生和刺激B淋巴细胞生长。
对9名豚草敏感者和8名非特应性受试者的淋巴细胞上清液中的可溶性CD23进行定量，这些淋巴细胞在体外由抗原E（豚草变应原1）、豚草粗提物和商陆丝裂原（PWM）刺激。
尽管PWM刺激在两组之间未产生显著差异，但在用抗原E和豚草粗提物刺激的非特应性患者细胞中，可溶性CD23的释放显著升高（P<0.05）。
这一发现支持了抗原和丝裂原激活可溶性CD23释放的不同途径的概念，并表明豚草敏感者和非特应性患者在可溶性CD23释放对豚草抗原刺激的反应上存在根本差异。
