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[固定化去甲肾上腺素对由因子 XII 激活的人血浆精氨酸酯酶的影响]

[Effect of immobilized noradrenaline on human plasma arginine esterase activated by factor XII].

作者信息

Popova L G, Zubairov D M, Zinkevich O D, Konchurina G Iu

出版信息

Biokhimiia. 1977 Mar;42(3):403-7.

PMID:861305
Abstract

An attempt to study direct hormonal regulation of the blood coagulating system by catecholamines, using the affinity chromatography method, was made. It was found that human blood plasma is adsorbed and the enzyme hydrolyzing N-benzoyl-L-arginine, is activated on the column. It was found that human blood plasma after the contact with norepinephrine loses its ability to increase the BAEE-esterase activity, when tanic acid, which activates factor XII (Hageman factor), was added.

摘要

尝试使用亲和色谱法研究儿茶酚胺对血液凝固系统的直接激素调节作用。结果发现,人血浆被吸附,且水解N-苯甲酰-L-精氨酸的酶在柱上被激活。还发现,当加入激活因子XII(哈格曼因子)的鞣酸时,与人去甲肾上腺素接触后的人血浆失去了增加BAEE酯酶活性的能力。

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