Altaner C, Cebecauer L
Biomedicine. 1977 Feb;26(1):42-7.
In the sera of one half of patients with sytemic lupus erythematosus (SLE) the endogenous and exogenous DNA polymerase activities were observed. The simultaneous presence of DNA polymerase activity and the antibodies to denatured DNA in the half of polymerase positive SLE sera was proved. The polymerase activity was not associated with virus-like particles. The endogenous polymerase activity probably used RNA, the exogenous one prefered DNA as a template. The determination of template requirement was complicated by the complexity of SLE sera. The product of polymerase activities were DNA-RNA hybrid and DNA. In some sera of the SLE patients without polymerase activity the antibodies against the polymerase were found. The occurrence of DNA polymerase activity and possible viral origin of SLE was discussed.
在一半系统性红斑狼疮（SLE）患者的血清中观察到了内源性和外源性DNA聚合酶活性。已证实在一半聚合酶阳性的SLE血清中同时存在DNA聚合酶活性和抗变性DNA抗体。聚合酶活性与病毒样颗粒无关。内源性聚合酶活性可能以RNA为模板，外源性聚合酶活性则更倾向于以DNA为模板。由于SLE血清的复杂性，模板需求的测定变得复杂。聚合酶活性的产物是DNA-RNA杂交体和DNA。在一些无聚合酶活性的SLE患者血清中发现了抗聚合酶抗体。文中讨论了DNA聚合酶活性的出现以及SLE可能的病毒起源。
