Fantuzzi G, Dinarello C A
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
J Leukoc Biol. 1996 Apr;59(4):489-93. doi: 10.1002/jlb.59.4.489.
Interleukin-1 (IL-1) plays a crucial role in the development of the pathophysiological responses to infection and inflammation. However, the relative contributions of IL-1 alpha and IL-1 beta remain to be clarified. IL-1 beta-deficient mice are a powerful tool to investigate the specific role of IL-1 beta in various experimental conditions. In this report, we summarize the response of IL-1 beta deficient mice to two different inflammatory stimuli, turpentine and endotoxin. Although IL-1 beta-deficient mice respond normally to the systemic administration of lipopolysaccharide (LPS), they do not develop an acute-phase response in the localized tissue damage model of turpentine injection. The results obtained using the IL-1 beta-deficient mice are compared here with those observed in the IL-1 beta-converting enzyme-deficient, IL-6-deficient, tumour necrosis factor-receptor p55-deficient, and interferon-gamma-receptor-deficient mice.
白细胞介素-1（IL-1）在感染和炎症的病理生理反应发展过程中起关键作用。然而，IL-1α和IL-1β的相对作用仍有待阐明。IL-1β缺陷小鼠是研究IL-1β在各种实验条件下具体作用的有力工具。在本报告中，我们总结了IL-1β缺陷小鼠对两种不同炎症刺激（松节油和内毒素）的反应。尽管IL-1β缺陷小鼠对脂多糖（LPS）的全身给药反应正常，但在松节油注射的局部组织损伤模型中它们并未产生急性期反应。在此将使用IL-1β缺陷小鼠获得的结果与在IL-1β转换酶缺陷、IL-6缺陷、肿瘤坏死因子受体p55缺陷和干扰素-γ受体缺陷小鼠中观察到的结果进行比较。
