Chu C S, Matylevich N P, McManus A T, Mason A D, Pruitt B A
United States Army Institute of Surgical Research, Fort Sam Houston, Texas, 78234-6315, USA.
J Trauma. 1996 May;40(5):738-42. doi: 10.1097/00005373-199605000-00009.
To observe the effect of 4 and 40 microA direct current (DC) on edema formation after burn injury in rats.
DESIGN, MATERIALS, AND METHODS: Silver-nylon wound dressings were used as either anodes (-) or cathodes (+) on 20% total body surface area full-thickness scalds in anesthetized male Sprague-Dawley rats. Untreated burned rats and rats treated with silver-nylon dressings without current were used as controls.
Immediately applied, continuous DC reduced burn edema by 17 to 48% at different times up to 48 hours postburn (p < 0.001). Neither reversal of electrode polarity nor change in current density had any significant effect on the results of treatment. Starting treatment during the first 8 hours postburn produced the least edema accumulation, but the reduction was significant even when DC was applied 36 hours afterburn. If started immediately after injury, treatment had to be continued a minimum of 8 hours to be most effective.
Direct electric current has a beneficial effect in reducing wound edema after burn injury.
观察4微安和40微安直流电对大鼠烧伤后水肿形成的影响。
设计、材料与方法：在麻醉的雄性Sprague-Dawley大鼠20%体表面积的全层烫伤处，使用银尼龙伤口敷料作为阳极（-）或阴极（+）。未处理的烧伤大鼠和使用无电流银尼龙敷料处理的大鼠作为对照。
立即施加的连续直流电在烧伤后48小时内的不同时间可使烧伤水肿减少17%至48%（p<0.001）。电极极性的反转和电流密度的变化均对治疗结果无显著影响。在烧伤后8小时内开始治疗产生的水肿积聚最少，但即使在烧伤后36小时施加直流电，水肿减少仍很显著。如果在受伤后立即开始治疗，治疗必须至少持续8小时才能达到最有效。
直流电对减轻烧伤后伤口水肿有有益作用。
