Marazzini L, Pelosi V, Vezzoli F, Pennasi R, Longhini E
Bull Eur Physiopathol Respir. 1977 Mar-Apr;13(2):219-29.
In this paper, we discuss results showing an increase of bronchial obstruction due to exposure in an iron foundry. The research has been conducted in two steps: in the first, we selected a sample of 100 subjects, all working in the iron foundry, who were affected only by small airway obstruction. In a second step, 30 months later, 99 of these subjects were re-examined and the present airway condition determined. In 43 subjects we found abnormal results of the tests indicating total airway obstruction after the 30 months. After properly accounting for ageing, we found that even in the subsample of non-smokers a deterioration had occurred, showing an effective contribution of environmental pollution. The use of RV, MMEF, CV, DLCO for detecting small airway obstruction is evaluated. The combination of RV, MMEF and CV is the most efficient mosaic of tests for the selection of subjects with small airway obstruction (89%) and with high probability of developing total airway obstruction (44%).
在本文中，我们讨论了有关因在铸铁厂接触而导致支气管阻塞增加的研究结果。该研究分两个阶段进行：第一阶段，我们选取了100名均在铸铁厂工作且仅受小气道阻塞影响的受试者作为样本。第二阶段，30个月后，对其中99名受试者进行了重新检查并确定了当前的气道状况。在43名受试者中，我们发现测试结果异常，表明30个月后出现了全气道阻塞。在适当考虑衰老因素后，我们发现即使在不吸烟的子样本中也出现了恶化情况，这表明环境污染有实际影响。对残气量（RV）、最大呼气中期流速（MMEF）、肺活量（CV）、一氧化碳弥散量（DLCO）用于检测小气道阻塞的情况进行了评估。RV、MMEF和CV的组合是用于筛选小气道阻塞受试者（89%）以及发生全气道阻塞可能性高的受试者（44%）的最有效测试组合。
