层粘连蛋白γ1基因中的正向元件在细胞分化过程中协同作用以激活高水平转录。
Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation.
作者信息
Chang H S, Kim N B, Phillips S L
机构信息
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA.
出版信息
Nucleic Acids Res. 1996 Apr 1;24(7):1360-8. doi: 10.1093/nar/24.7.1360.
Abstract
Transcription of the murine laminin gamma 1 gene is activated during retinoic acid/cAMP induced differentiation of F9 embryonal carcinoma cells. Positive transcription control elements associated with two DNase I hypersensitive regions in the large first intron of the gene have been identified which confer a differentiation response on the laminin gamma 1 promoter. However, the kinetics of transcriptional activation suggest each DNA region interacts with transcription factors appearing at different times during differentiation. Synergy between the two regions in cis causes high level activation.
摘要
在视黄酸/环磷酸腺苷诱导的F9胚胎癌细胞分化过程中，小鼠层粘连蛋白γ1基因的转录被激活。已鉴定出与该基因大的第一内含子中两个DNA酶I超敏区域相关的正向转录控制元件，这些元件赋予层粘连蛋白γ1启动子分化反应。然而，转录激活的动力学表明，每个DNA区域与分化过程中不同时间出现的转录因子相互作用。顺式作用中两个区域之间的协同作用导致高水平激活。
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