Bende M, Fukami M, Arfors K E, Mark J, Stierna P, Intaglietta M
Department of Applied Mechanics and Engineering Sciences, University of California-San Diego, USA.
Ann Otol Rhinol Laryngol. 1996 Mar;105(3):222-5. doi: 10.1177/000348949610500309.
This investigation was designed to evaluate the effect of the common topical nasal decongestant oxymetazoline hydrochloride on the early local tissue defense in an experimental bacterial infection. For that purpose, a bilateral infection of the maxillary sinus was induced in 14 rabbits. Nose drops (oxymetazoline) were instilled in one nasal cavity, and placebo in the other. After 48 hours, the degree of infection was judged by using a semiquantitative inflammatory score to evaluate histologic preparations of the maxillary sinuses. On the oxymetazoline-treated side, we found a significantly higher degree of inflammation. We conclude that oxymetazoline nose drops, commonly used in acute rhinitis and sinusitis, interfere with the normal defense mechanisms during bacterially induced sinusitis, possibly by a decrease in mucosal blood flow.
本研究旨在评估常用局部鼻减充血剂盐酸羟甲唑啉在实验性细菌感染中对早期局部组织防御功能的影响。为此，在14只家兔中诱发双侧上颌窦感染。在一侧鼻腔滴入滴鼻剂（羟甲唑啉），另一侧滴入安慰剂。48小时后，通过使用半定量炎症评分来评估上颌窦的组织学标本，从而判断感染程度。在使用羟甲唑啉治疗的一侧，我们发现炎症程度明显更高。我们得出结论，常用于急性鼻炎和鼻窦炎的羟甲唑啉滴鼻剂在细菌性鼻窦炎期间会干扰正常防御机制，可能是通过减少黏膜血流来实现的。
