Ohtsubo T, Saito H, Tanaka N, Noda I, Saito T, Kano E
Department of Otolaryngology, Fukui Medical School, Japan.
Anticancer Res. 1996 Jan-Feb;16(1):297-300.
To discover the point of maximum interactive effect, we examined the time sequence of high (above (42.5 degrees C) or low (below 42.5 degrees C) -hyperthermia and cis-diammine dichloroplatinum (II) (CDDP). Simultaneous or post-hyperthermic CDDP (0.5 micrograms/ml) treatment at 43 degrees C resulted in a slight synergistic effect, with thermoenhancement ratios (TER) of 1.42 or 1.38, respectively, and there was a significant increase CDDP uptake after both combinations compared with pre-hyperthermic CDDP treatment. However, at 42 degrees C, the maximal interaction (TER = 8.57) was obtained when KB cells were simultaneously heated with CDDP, there was also a significant increase of CDDP uptake by simultaneous procedures compared with pre or post-hyperthermic CDDP treatment. These results indicate that simultaneous or post-hyperthermic CDDP treatment for high-hyperthermia and simultaneous CDDP treatment for low-hyperthermia are the most effective means of CDDP thermochemotherapy with hyperthermia.
为了发现最大交互效应点，我们研究了高温（高于42.5摄氏度）或低温（低于42.5摄氏度）热疗与顺二氯二氨铂（II）（CDDP）的时间顺序。在43摄氏度同时或热疗后给予CDDP（0.5微克/毫升）治疗产生了轻微的协同效应，热增强比（TER）分别为1.42或1.38，并且与热疗前给予CDDP治疗相比，两种联合治疗后CDDP摄取均显著增加。然而，在42摄氏度时，当KB细胞与CDDP同时加热时可获得最大交互作用（TER = 8.57），与热疗前或热疗后给予CDDP治疗相比，同时处理时CDDP摄取也显著增加。这些结果表明，高温时同时或热疗后给予CDDP治疗以及低温时同时给予CDDP治疗是热疗联合CDDP热化疗的最有效方法。
