Korabiowska M, Mirecka J, Brinck U, Hoefer K, Marx D, Schauer A
Department of Pathology, Georg August University Göttingen, Germany.
Anticancer Res. 1996 Jan-Feb;16(1):471-4.
28 naevi, 43 malignant melanomas and 16 lymph nodes with melanoma metastases were stained immunohistochemically for the expression of cerbB3 oncoprotein. using antibody RTJ1. Positive reaction was found in 60% of naevi and in 25% of melanoma cases. The difference in frequency of the reaction occurrence between naevi and melanomas was statistically highly significant (p = 0.0017). In naevi, the percentage of cerbB3 positive cells (56.5%) was also significantly higher (p = 0.021) as compared with that of melanomas (37%). The cerbB3 positive cells were found only in cases without metastases. Positive reaction was also observed in 4 out of 16 investigated lymph nodes with melanoma metastases. The role of cerbB in the development of melanoma is discussed.
对28个痣、43例恶性黑色素瘤以及16个伴有黑色素瘤转移的淋巴结进行免疫组织化学染色，以检测cerbB3癌蛋白的表达，使用抗体RTJ1。在60%的痣和25%的黑色素瘤病例中发现阳性反应。痣和黑色素瘤中反应发生频率的差异在统计学上具有高度显著性（p = 0.0017）。在痣中，cerbB3阳性细胞的百分比（56.5%）也显著高于黑色素瘤（37%）（p = 0.021）。仅在无转移的病例中发现cerbB3阳性细胞。在16个被研究的伴有黑色素瘤转移的淋巴结中，有4个也观察到阳性反应。文中讨论了cerbB在黑色素瘤发生发展中的作用。
