Korabiowska M, Brinck U, Hoenig J F, Bartkowski S B, Kellner S, Marx D, Schauer A
Department of Pathology, Georg August University Göttingen, Germany.
Anticancer Res. 1995 May-Jun;15(3):885-9.
DO-7 antibody against p-53 antigen was applied for investigation of melanomas of facial skin (25 cases), oral cavity (17 cases), eye (18 cases) and naevi (25 cases). The p-53 index value (% of p-53 positive cells) was correlated with the thickness of the tumour, the presence of metastases and survival time. The difference in p-53 index between naevi and melanomas was statistically significant (p < < 0.01). A significant correlation was found between the p-53 index value and the thickness of the tumour, the presence of metastases and follow-up for patients with skin, oral and ocular melanomas. The possible diagnostic and prognostic significance of p-53 antigen in melanomas and naevi of the head and neck area is discussed.
应用抗p - 53抗原的DO - 7抗体对25例面部皮肤黑色素瘤、17例口腔黑色素瘤、18例眼部黑色素瘤及25例痣进行研究。p - 53指数值（p - 53阳性细胞的百分比）与肿瘤厚度、转移情况及生存时间相关。痣与黑色素瘤之间的p - 53指数差异具有统计学意义（p << 0.01）。在皮肤、口腔和眼部黑色素瘤患者中，发现p - 53指数值与肿瘤厚度、转移情况及随访之间存在显著相关性。讨论了p - 53抗原在头颈部黑色素瘤和痣中的可能诊断及预后意义。
