Wielosz M, Młynarczyk M, Kleinrok Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Pol J Pharmacol. 1995 Jul-Aug;47(4):279-84.
Recent studies have shown that lithium pretreatment of rats potentiates the convulsant effect of pilocarpine. A large body of evidence support the hypothesis that calcium channel antagonists possess antiepileptic properties in various models of epilepsy. This study was designed to investigate effect of calcium channel antagonist, nifedipine on lithium-pilocarpine-induced convulsions in rats. Pretreatment of rats with nifedipine (5 or 10 mg/kg) as well as with a calcium channel agonist BAY k-8644 (2 mg/kg) increased convulsant effect induced by lithium and pilocarpine. The facilitating effect of nifedipine on lithium-pilocarpine-induced convulsions was prevented by pretreatment with a cholinergic antagonist atropine. It can be concluded that nifedipine facilitates convulsions in lithium-pilocarpine model of epilepsy and that cholinergic system may be involved in this effect.
最近的研究表明，对大鼠进行锂预处理可增强毛果芸香碱的惊厥作用。大量证据支持这样的假说，即钙通道拮抗剂在各种癫痫模型中具有抗癫痫特性。本研究旨在调查钙通道拮抗剂硝苯地平对锂-毛果芸香碱诱导的大鼠惊厥的影响。用硝苯地平（5或10毫克/千克）以及钙通道激动剂BAY k-8644（2毫克/千克）对大鼠进行预处理，会增强锂和毛果芸香碱诱导的惊厥作用。用胆碱能拮抗剂阿托品预处理可防止硝苯地平对锂-毛果芸香碱诱导惊厥的促进作用。可以得出结论，硝苯地平可促进锂-毛果芸香碱癫痫模型中的惊厥发作，且胆碱能系统可能参与了这一作用。
