α干扰素影响移植后淋巴细胞增生性疾病中的免疫反应。
Interferon-alpha affects the immune response in post-transplant lymphoproliferative disorder.
作者信息
Faro A, Kurland G, Michaels M G, Dickman P S, Greally P G, Spichty K J, Noyes B B, Boas S R, Fricker F J, Armitage J M, Zeevi A
机构信息
Division of Pulmonology, Infectious Disease, and Cardiology, Children's Hospital of Pittsburgh, Pennsylvania, USA.
出版信息
Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1442-7. doi: 10.1164/ajrccm.153.4.8616579.
Post-transplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV) and characterized by fever, lymphadenopathy, and graft dysfunction. We describe the clinical course of an EBV seronegative 11-yr-old boy who underwent double lung transplantation and subsequently developed PTLD in the graft. A reduction in immunosuppression and the addition of acyclovir did not result in improvement. Treatment with interferon-alpha (IFN-alpha), however, led to dramatic clinical, radiographic, and histologic improvement. Semiquantitative measurements of cytokine mRNA in his bronchoalveolar lavage cells prior to therapy with IFN-alpha revealed high levels of IL-4 and IL-10 mRNA, which decreased significantly with treatment. We speculate that the beneficial effect of IFN-alpha in the treatment of PTLD is directly related to the inhibition of type 2 helper (Th2-like) T-cells.
移植后淋巴细胞增生性疾病（PTLD）与 Epstein-Barr 病毒（EBV）相关，其特征为发热、淋巴结病和移植物功能障碍。我们描述了一名 11 岁 EBV 血清学阴性男孩的临床病程，该男孩接受了双肺移植，随后在移植物中发生了 PTLD。免疫抑制的减少和阿昔洛韦的添加并未带来改善。然而，使用干扰素-α（IFN-α）治疗导致了显著的临床、影像学和组织学改善。在使用 IFN-α治疗之前，对其支气管肺泡灌洗细胞中细胞因子 mRNA 的半定量测量显示 IL-4 和 IL-10 mRNA 水平较高，治疗后显著下降。我们推测 IFN-α在 PTLD 治疗中的有益作用与对 2 型辅助（Th2 样）T 细胞的抑制直接相关。
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