Senel M F, Van Buren C T, Etheridge W B, Barcenas C, Jammal C, Kahan B D
Department of Surgery, University of Texas Medical School-Houston 7703, USA.
Clin Nephrol. 1996 Jan;45(1):18-21.
Nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS) is a common cause of renal failure leading to transplantation. Various immunosuppressive drugs, including cyclosporine, have been used in the treatment of FSGS with varying degrees of success. The patient described herein was afflicted with end stage renal disease secondary to steroid-resistant nephrotic syndrome due to FSGS with coexistent Kimura's disease. After kidney transplantation, the patient experienced a remission of both the Kimura's disease and the nephrotic syndrome in the native kidneys, leading to the resumption of renal function by the native kidneys in spite of severe transplant glomerulopathy. This case suggests that certain cases of FSGS without extensive interstitial disease may benefit from aggressive treatment with a combination of immunosuppressive drugs.
局灶节段性肾小球硬化（FSGS）继发的肾病综合征是导致肾衰竭进而需要进行移植的常见原因。包括环孢素在内的各种免疫抑制药物已被用于治疗FSGS，取得了不同程度的成功。本文所述患者患有FSGS继发的类固醇抵抗性肾病综合征所致的终末期肾病，并伴有木村病。肾移植后，患者的木村病和原肾肾病综合征均得到缓解，尽管存在严重的移植肾小球病，但原肾仍恢复了肾功能。该病例表明，某些无广泛间质疾病的FSGS病例可能受益于免疫抑制药物联合的积极治疗。
