Shenaq S M, Rabinovsky E D
Plastic Surgery Research Laboratory, Baylor College of Medicine, Houston, Texas, USA.
Clin Plast Surg. 1996 Jan;23(1):157-71.
In the future, gene therapy will become the standard treatment for enhancing wound healing and nerve and muscle regeneration and for preventing or treating vessel thrombosis, areas critical to the plastic surgeon and the patient. This review has focused on factors that are either currently used in a clinical situation or have the promise of being developed for clinical use. The role of gene therapy applied to these areas will be to locally place therapeutic genes at the site of injury or surgical repair, which will replace the need to systemically administer therapeutic agents that may have toxic effects, and to express factors in low abundance but at effective and safe levels. This strategy is to produce enough agent to have a therapeutic effect. The use of tissue-specific promoters will be beneficial in localizing the production of agents to certain cell types. Gene therapeutic approaches used in plastic surgery may have a significant impact on the health care system by increasing efficiency of treatment and reducing health care costs. The accelerated pace of basic research in gene therapy will result in clinical applications in the near future.
未来，基因治疗将成为促进伤口愈合、神经和肌肉再生以及预防或治疗血管血栓形成的标准治疗方法，这些领域对整形外科医生和患者至关重要。本综述重点关注了目前已用于临床或有望开发用于临床的因素。基因治疗应用于这些领域的作用将是在损伤或手术修复部位局部放置治疗性基因，这将取代全身给药可能具有毒性作用的治疗药物的需求，并以低丰度但有效且安全的水平表达因子。这种策略是产生足够的药物以产生治疗效果。使用组织特异性启动子将有利于将药物的产生定位到某些细胞类型。整形外科中使用的基因治疗方法可能会通过提高治疗效率和降低医疗成本对医疗保健系统产生重大影响。基因治疗基础研究的加速进展将在不久的将来带来临床应用。
