Foschini M P, Fornelli A, Peterse J L, Mignani S, Eusebi V
Institutes of Anatomic Pathology and Radiology, University of Bologna, Italy.
Hum Pathol. 1996 Feb;27(2):178-83. doi: 10.1016/s0046-8177(96)90372-x.
Thirty cases of ductal carcinoma in situ (DCIS) of the breast, showing histological microcalcifications, were studied to clarify their mechanism of formation. Undecalcified sections revealed three types of calcium precipitates: type I and II granular calcifications (GCs) and laminar calcifications (LCs). In type I GCs the core on which the calcium had deposited was constituted mainly by nuclear debris. Type II GCs were predominantly composed by mucosubstances. LCs were the result of calcium deposits on mucoid or proteinaceous material, arranged in concentric lamellae. LCs and type II GCs were mainly present in well and intermediately differentiated DCIS. Type I GCs were observed in only DCIS with necrosis, frequently being present in intermediately and poorly differentiated DCIS.
对30例伴有组织学微钙化的乳腺导管原位癌（DCIS）进行研究，以阐明其形成机制。未脱钙切片显示出三种类型的钙沉淀物：I型和II型颗粒状钙化（GCs）以及层状钙化（LCs）。在I型GCs中，钙沉积的核心主要由核碎片构成。II型GCs主要由黏液物质组成。LCs是钙沉积在黏液样或蛋白质样物质上的结果，呈同心层状排列。LCs和II型GCs主要存在于高分化和中分化的DCIS中。I型GCs仅在伴有坏死的DCIS中观察到，常见于中分化和低分化的DCIS中。
