Dewan V, Patwari A K, Jain M, Dewan N
Diarrhea Training and Treatment Unit, Kalawati Saran Children's Hospital, New Delhi.
Indian Pediatr. 1995 Jan;32(1):21-5.
Effect of vitamin A supplementation on duration of diarrhea was evaluated in 108 cases between 6 months to 5 years of age suffering from acute diarrhea of less than 3 days duration and results were compared with equal number of age and sex matched controls having comparable feeding pattern, nutritional and socio-economic status and clinical profile who did not receive vitamin A supplementation. There was no significant difference in the mean duration of diarrhea in cases who received vitamin A and the controls. However, on subgroup analysis of the study and control groups a significant (p = 0.009) beneficial effect of vitamin A supplementation was noticed in cases who had a pre-existing vitamin A deficiency with CIC stage 3/5 and above. Even though vitamin A supplementation in malnourished children did not significantly alter the duration of diarrhea, a beneficial effect was observed in children who had CIC state 3 and above in association with malnutrition (p = 0.025). Our results indicate that vitamin A supplementation does not significantly reduce the duration of a diarrheal episode. However, in children with pre-existing vitamin A deficiency particularly those who have associated malnutrition it may have a beneficial effect.
对108例6个月至5岁、急性腹泻病程少于3天的患儿，评估补充维生素A对腹泻持续时间的影响，并将结果与同等数量、年龄和性别匹配、喂养方式、营养及社会经济状况和临床特征相当但未补充维生素A的对照组进行比较。接受维生素A治疗的患儿与对照组在腹泻平均持续时间上无显著差异。然而，对研究组和对照组进行亚组分析时发现，在已有维生素A缺乏且CIC分期为3/5及以上的患儿中，补充维生素A有显著（p = 0.009）的有益效果。尽管在营养不良儿童中补充维生素A并未显著改变腹泻持续时间，但在伴有营养不良且CIC状态为3及以上的儿童中观察到了有益效果（p = 0.025）。我们的结果表明，补充维生素A并不能显著缩短腹泻发作的持续时间。然而，在已有维生素A缺乏的儿童中，尤其是那些伴有营养不良的儿童，补充维生素A可能会有有益效果。
