水合氯醛与咪达唑仑用于新生儿神经影像学检查镇静的比较。
Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies.
作者信息
McCarver-May D G, Kang J, Aouthmany M, Elton R, Mowery J L, Slovis T L, Kauffman R
机构信息
Department of Pediatrics, Children's Hospital of Michigan, Detroit, USA.
出版信息
J Pediatr. 1996 Apr;128(4):573-6. doi: 10.1016/s0022-3476(96)70375-x.
PMID:8618198
Abstract
In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose.
摘要
在一项针对七名接受神经影像学检查的足月儿的交叉研究中，水合氯醛（口服给药，剂量为75毫克/千克）比咪达唑仑（静脉注射，剂量为0.2毫克/千克）更有效（p<0.05），但在毒性作用方面相似。因此，新药不一定更好，即使是单次口服镇静剂剂量后，监测也是必不可少的。
Zotero 插件