使用吗氯贝胺的三次自杀未遂事件。

Three suicide attempts with moclobemide.

作者信息

Iwersen S, Schmoldt A

机构信息

University of Hamburg, Germany.

出版信息

J Toxicol Clin Toxicol. 1996;34(2):223-5. doi: 10.3109/15563659609013774.

DOI:10.3109/15563659609013774

PMID:8618258

Abstract

OBJECTIVE

To report plasma moclobemide, course and outcome of two cases of overdose with moclobemide alone and one case of combined ingestion of moclobemide and clomipramide.

METHODS

Moclobemide identification and quantification was achieved by gas chromatography-mass spectrometry after alkaline extraction.

CASE REPORTS

In case 1, plasma moclobemide was 2.8 mg/L with 1.8 mg/L clomipramide; in case 2, 18 mg/L; in case 3 60.9 mg/L and 4.6 mg/L 12 hours later. None of the patients showed serious effects during 24 hours of observation. Plasma moclobemide at 10 to 30 times therapeutic was not associated with major toxic effects. Moclobemide seems to be considerably less toxic than tricyclic antidepressants.

摘要

目的

报告两例单独过量服用吗氯贝胺及一例同时服用吗氯贝胺与氯米帕明的血浆吗氯贝胺浓度、病程及转归。

方法

碱性萃取后，采用气相色谱 - 质谱联用仪对吗氯贝胺进行鉴定和定量分析。

病例报告

病例1中，血浆吗氯贝胺浓度为2.8mg/L，氯米帕明浓度为1.8mg/L；病例2中，吗氯贝胺浓度为18mg/L；病例3中，吗氯贝胺浓度为60.9mg/L，12小时后为4.6mg/L。在24小时的观察期内，所有患者均未出现严重不良反应。血浆吗氯贝胺浓度达到治疗浓度10至30倍时，未出现重大毒性反应。吗氯贝胺的毒性似乎远低于三环类抗抑郁药。