Menéndez V, Cofán F, Talbot-Wright R, Ricart M J, Gutiérrez R, Carretero P
Department of Urology, Hospital Clinic i Provincial, University of Barcelona, Spain.
J Urol. 1996 Jun;155(6):2001-4.
We evaluated the urodynamic changes produced by insulin-dependent diabetes mellitus with end stage renal disease.
A urodynamic evaluation was performed on 51 young patients (mean age plus or minus standard deviation 35 +/- 6 years) with long-term diabetes mellitus (average 21 +/- 6 years) and end stage renal disease (86% on dialysis).
The urodynamic study was abnormal in 84% of the patients. The bladder was hypersensitive in 39% and hyposensitive in 30% of the cases, and maximum vesical capacity was greater than 600 ml. in 33%. An acontractile detrusor was noted in 6% of the patients, while 4% had detrusor hyperreflexia and 35% had bladder outlet obstruction.
A high frequency of vesical alterations was observed, which were modified by association of progressive vesical dysfunction and diabetes mellitus. In diabetes mellitus dialysis protects against detrusor hypocontractility but predisposes the patients to have bladder obstruction.
我们评估了终末期肾病伴胰岛素依赖型糖尿病所产生的尿动力学变化。
对51例患有长期糖尿病（平均21±6年）和终末期肾病（86%接受透析）的年轻患者（平均年龄±标准差35±6岁）进行了尿动力学评估。
84%的患者尿动力学检查异常。39%的病例膀胱过敏，30%的病例膀胱低敏，33%的病例最大膀胱容量大于600毫升。6%的患者存在逼尿肌无收缩，4%的患者有逼尿肌反射亢进，35%的患者有膀胱出口梗阻。
观察到膀胱改变的发生率很高，这些改变因渐进性膀胱功能障碍与糖尿病的关联而有所改变。在糖尿病患者中，透析可预防逼尿肌收缩力减弱，但使患者易发生膀胱梗阻。
