丁基羟基甲苯对大鼠的毒性作用。
Toxic effects of butylated hydroxytoluene on rats.
作者信息
Saheb J L, Saheb S A
出版信息
Can J Comp Med. 1977 Apr;41(2):195-201.
A study involving 96 weanling rats of both sexes was conducted to evaluate the effects of the antioxidant butylated hydroxytoluene on the plasma and liver lipid components. Comparative observations in the dietary content of butylated hydroxytoluene in ad libitum and underfed rats. A sex difference in the effects of butylated hydroxytoluene was noted. Butylated hydroxytoluene had a greater deleterious effect on the growth of the male than of the female rat, especially at the 0.5% dietary level (P less than 0.01). At this level, it also increased the relative weight of the liver (P less than 0.01) but had little effect on brain, heart and kidney in both sexes. The enlarged liver showed a marked elevation in the concentration of total lipids and of both total and esterified cholesterol. There were striking increases in the plasma total and esterified cholesterol and phospholipid levels in the butylated hydroxytoluene treated animals buy the triglycerides remained unaffected. The results obtained were more manifest in animals with restricted dietary intake. The changes observed in the lipid components occurred in parallel with the increasing amounts of the antioxidant in the diet. The effect of butylated hydroxytoluene on lipid metabolism is discussed.
进行了一项涉及96只雌雄断奶大鼠的研究，以评估抗氧化剂丁基羟基甲苯对血浆和肝脏脂质成分的影响。对随意进食和限食大鼠饮食中丁基羟基甲苯含量进行了对比观察。发现丁基羟基甲苯的作用存在性别差异。丁基羟基甲苯对雄性大鼠生长的有害影响大于雌性大鼠，尤其是在饮食水平为0.5%时（P<0.01）。在此水平下，它还增加了肝脏的相对重量（P<0.01），但对两性的脑、心脏和肾脏影响较小。肝脏肿大显示总脂质以及总胆固醇和酯化胆固醇的浓度显著升高。在丁基羟基甲苯处理的动物中，血浆总胆固醇、酯化胆固醇和磷脂水平显著升高，但甘油三酯未受影响。在饮食摄入受限的动物中获得的结果更为明显。观察到的脂质成分变化与饮食中抗氧化剂含量的增加同时发生。讨论了丁基羟基甲苯对脂质代谢的影响。
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