丁基羟基甲苯对大鼠肝脏脂质组成的影响。
Effect of butylated hydroxytoluene on the lipid composition of rat liver.
作者信息
Takahashi O, Hiraga K
出版信息
Toxicology. 1981;22(2):161-70. doi: 10.1016/0300-483x(81)90115-3.
Hepatic lipids were studied in Sprague-Dawley male rats given butylated hydroxytoluene(BHT) at a level of 1.20% for 1 week. BHT significantly increased cholesteryl esters and phospholipids but decreased triglycerides, non-esterified fatty acids and diglycerides. BHT also increased phosphatidylethanolamine or decreased phosphatidylinositol and lysophosphatidylcholine. Fatty acid composition of each lipid class was also changed by BHT-feeding. The decrease in 16 : 1/16 : 0, 18 1/18 : 0 and 20 : 4/18 :2 ratios of total lipids, non-esterified fatty acids or phospholipids of BHT-given rats suggests that BHT decreases the activity of fatty acid desaturase in the liver.
对给予1.20%丁基羟基甲苯（BHT）的斯普拉格-道利雄性大鼠进行了为期1周的肝脏脂质研究。BHT显著增加了胆固醇酯和磷脂，但降低了甘油三酯、非酯化脂肪酸和甘油二酯。BHT还增加了磷脂酰乙醇胺或降低了磷脂酰肌醇和溶血磷脂酰胆碱。通过喂食BHT，每种脂质类别的脂肪酸组成也发生了变化。给予BHT的大鼠总脂质、非酯化脂肪酸或磷脂的16:1/16:0、18:1/18:0和20:4/18:2比率降低，这表明BHT降低了肝脏中脂肪酸去饱和酶的活性。
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