Kolosova N G, Kolpakov A R, Panin L E
Vopr Med Khim. 1995 Nov-Dec;41(6):16-9.
The content of lipid peroxidation (LPO) products and tocopherol was studied in the plasma, adrenals, brown fat, heart, thymus, liver tissue, microsomes and mitochondria of Wistar rats in various periods of cold acclimation (+4 degrees C during 2, 5, 24 hours and 5, 10, 15, and 49 days). Within the first 24 hours of cold exposure, there were periods of low levels of LPO products which, as their following elevation, did not coincide in time both for various tissues and for subcellular structures. The liver was used as an example to show that the activity of glutathione reductase and glutathione peroxidase enhanced. The rats' adaptation to moderately low temperatures occurred with the stabilized LPO processes and elevated body's tissue tocopherol levels: in the first hours of exposure by mobilizing its endogenous stores, on long-term exposure by enhancing its utilization from the diet.
研究了不同冷适应时期（2、5、24小时以及5、10、15和49天，温度为+4摄氏度）Wistar大鼠的血浆、肾上腺、棕色脂肪、心脏、胸腺、肝组织、微粒体和线粒体中脂质过氧化（LPO）产物和生育酚的含量。在冷暴露的前24小时内，存在LPO产物水平较低的时期，随后其升高时，不同组织和亚细胞结构在时间上并不一致。以肝脏为例表明，谷胱甘肽还原酶和谷胱甘肽过氧化物酶的活性增强。大鼠对适度低温的适应发生在LPO过程稳定且机体组织生育酚水平升高的情况下：在暴露的最初几个小时通过动员其内源性储备，在长期暴露时通过提高从饮食中的利用率。
