Mouren X, Caillard P, Massonneau M, Thébault B
Medical Center, Tenon Hospital, Paris, France.
Angiology. 1996 Apr;47(4):329-36. doi: 10.1177/000331979604700402.
Distal transcutaneous oxygen pressure measurement (TcPo2) is a noninvasive method of evaluating tissular hypoxemia in peripheral arterial disease. The poststress area of hypoxemia is a usefull technique for globally quantifying different parameters represented by TcPo2 curves during exercise. Although its use is increasingly widespread, the reproducibility of this method is poorly documented. TcPo2 was monitored three times at twenty-four hour intervals in 5 patients with stage II obliterative arterial disease during a treadmill walking test. In order to get uniform measurement conditions, each patient remained lying and then stood until TcPo2 became stable. The stress duration was calculated so that the pain step could not be reached. TcPo2 curves were digitized and a specific image analyzer was used to make replicate measurements. The area under the curve was computed, the horizontal axis determining the mean TcPo2 value at rest, the vertical axis representing the end of the exercise period. The corresponding areas under the curves ranged from 34 to 2212 mm2 (573.60; SD 826). Significant correlation coefficients were obtained among replicate measurements (first-second day, first-third day). However, owing to the wide range of area values, the authors decided to compute and use the coefficient of variation (STD/mean), since it was more representative of reproducibility. The mean of its value for 5 patients was 21%. Observation of the examination conditions resulted in several findings, especially the ability of certain patients to adapt their efforts to the exercise. These results indicate that TcPo2 poststress area measurements are reproducible, but the conditions of the exercise have to be rigorously defined and may still be improved.
经皮氧分压远端测量（TcPo2）是评估外周动脉疾病中组织低氧血症的一种非侵入性方法。低氧血症的应激后区域是一种有用的技术，可用于全局量化运动期间TcPo2曲线所代表的不同参数。尽管其应用越来越广泛，但该方法的可重复性记录较少。在跑步机步行试验期间，对5例II期闭塞性动脉疾病患者每隔24小时监测三次TcPo2。为了获得统一的测量条件，每位患者先躺着，然后站立，直到TcPo2稳定。计算应激持续时间，以使疼痛阶段无法达到。将TcPo2曲线数字化，并使用特定的图像分析仪进行重复测量。计算曲线下面积，横轴确定静息时的平均TcPo2值，纵轴代表运动期结束。曲线下相应面积范围为34至2212平方毫米（573.60；标准差826）。重复测量之间（第一天至第二天，第一天至第三天）获得了显著的相关系数。然而，由于面积值范围较宽，作者决定计算并使用变异系数（标准差/平均值），因为它更能代表可重复性。5例患者该值的平均值为21%。对检查条件的观察得出了几个发现，特别是某些患者能够根据运动调整其努力程度。这些结果表明，应激后区域的TcPo2测量是可重复的，但运动条件必须严格定义，并且仍可能需要改进。
