Donaldson S S
Cancer Res. 1977 Jul;37(7 Pt 2):2407-13.
Curative doses of radiotherapy, when directed to any portion of the gastrointestinal tract, may result in serious nutritional consequences from the effects of radiation on the altered function of normal tissues. Symptoms from radiotherapy resulting in nutritional alterations are usually dependent upon dose, time, and fractionation of radiation administered, and the volume included in the treatment field. These effects directly related to radiation may be enhanced by other associated cancer therapy, e.g., surgery or chemotherapy. Careful observation and prompt attention to supportive therapy are mandatory to minimize the nutritional consequences of radiation injury. Well-designed clinical trials are necessary to demonstrate any possible increased tolerance to radiation therapy and the preventative benefits of nutritional support.
当对胃肠道的任何部位进行治疗剂量的放射治疗时，辐射对正常组织功能改变的影响可能会导致严重的营养后果。放疗导致营养改变的症状通常取决于所给予辐射的剂量、时间、分次情况以及治疗野所包含的体积。与放疗直接相关的这些影响可能会因其他相关的癌症治疗（如手术或化疗）而加重。必须进行仔细观察并及时给予支持性治疗，以尽量减少辐射损伤的营养后果。需要精心设计的临床试验来证明对放射治疗可能增加的耐受性以及营养支持的预防益处。
