Sathananthan A H
Cell Tissue Res. 1977 Apr 20;179(3):393-9. doi: 10.1007/BF00221109.
Initial observations on the effects of 5,7-DHT on the myenteric plexus of Mytilus reveal extensive lesioning of monoamine nerves containing dense-cored vesicles. At least, two types of monoaminergic nerves could be recognized among the degenerating axons. The most affected were profiles with a predominance of large granular vesicles (56-200 nm) which resemble possible indoleamine nerves in the lamprey gut. The other type had small granular vesicles (40-56 nm) resembling catecholamine nerves of vertebrates. These two types of nerves possibly represent serotonergic and dopaminergic nerves, in accordance with pharmacological, biochemical and physiological evidence available in molluscs. There were, however, nerves with a population of medium-sized granular vesicles (56-130 nm) which were also damaged. Two other types of nerve profiles were unaffected by the drug. One conforms to cholinergic nerves while the other resembles "purinergic" nerves in the vertebrate gut. These results confirm previous studies with dihydroxytryptamines on molluscan smooth muscle.
对5,7 - 二氢睾酮（5,7-DHT）对贻贝肌间神经丛影响的初步观察显示，含有致密核心小泡的单胺能神经出现广泛损伤。在退化的轴突中至少可识别出两种类型的单胺能神经。受影响最严重的是那些以大量大颗粒小泡（56 - 200纳米）为主的形态，这些小泡类似于七鳃鳗肠道中可能的吲哚胺能神经。另一种类型有小颗粒小泡（40 - 56纳米），类似于脊椎动物的儿茶酚胺能神经。根据软体动物现有的药理学、生物化学和生理学证据，这两种类型的神经可能分别代表5-羟色胺能神经和多巴胺能神经。然而，也有一些含有中等大小颗粒小泡（56 - 130纳米）的神经受到了损伤。另外两种神经形态不受该药物影响。一种符合胆碱能神经，而另一种类似于脊椎动物肠道中的“嘌呤能”神经。这些结果证实了先前用二羟基色胺对软体动物平滑肌进行的研究。
