Martin L B, Kita H, Leiferman K M, Gleich G J
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Int Arch Allergy Immunol. 1996 Mar;109(3):207-15. doi: 10.1159/000237239.
For over 100 years, the eosinophil has been associated with allergic disease. At present, eosinophils appear to be associated pathologically with asthma, atopic dermatitis, allergic rhinitis, eosinophilic gastroenteritis, and certain eye diseases. The effector functions of eosinophils appear to be derived primarily from release of lipid mediators and proteins, including cytokines and granule proteins. Eosinophil degranulation results in the release of several cytotoxic cationic granule proteins. Furthermore, release of cytokines by eosinophils and other cells involved in inflammation amplifies and regulates localized immune responses. Altogether, the eosinophil's capacity to release and be influenced by a variety of mediators, including the granule proteins and cytokines, implicates this cell in the pathology of inflammation and in the perpetuation of the inflammatory response.
100多年来，嗜酸性粒细胞一直与过敏性疾病相关。目前，嗜酸性粒细胞在病理上似乎与哮喘、特应性皮炎、过敏性鼻炎、嗜酸性粒细胞性胃肠炎及某些眼部疾病有关。嗜酸性粒细胞的效应功能似乎主要源于脂质介质和蛋白质的释放，包括细胞因子和颗粒蛋白。嗜酸性粒细胞脱颗粒导致几种细胞毒性阳离子颗粒蛋白的释放。此外，嗜酸性粒细胞和其他参与炎症的细胞释放细胞因子会放大并调节局部免疫反应。总之，嗜酸性粒细胞释放多种介质并受其影响的能力，包括颗粒蛋白和细胞因子，表明该细胞参与炎症病理过程以及炎症反应的持续。
