Bokor P, DiNardo S
The Rockefeller University, New York 10021-6399, USA.
Development. 1996 Apr;122(4):1083-92. doi: 10.1242/dev.122.4.1083.
Rows of cells that flank the parasegment boundary make up a signaling center within the epidermis of the Drosophila embryo. Signals emanating from these cells, encoded by hedgehog (hh) and wingless (wg), are shown to be required for all segment pattern dorsally. Wg activity is required for the differentiation of one cell type, constituting half the parasegment. The gene lines appears to act in parallel to the Wg pathway in the elaboration of this cell type. Hh activity is responsible for three other cell types in the parasegment. Some cell types are specified as Hh activity and interfere with the function of patched, analogous to patterning of imaginal discs. However, some pattern is independent of the antagonism of patched by Hh, and relies instead on novel interactions with lines. Lastly, we provide evidence that decapentaplegic does not mediate patterning by Hh in the dorsal epidermis.
位于副节边界两侧的细胞排构成了果蝇胚胎表皮内的一个信号中心。由刺猬蛋白（hh）和无翅蛋白（wg）编码的从这些细胞发出的信号被证明是背部所有节段模式所必需的。Wg活性是一种细胞类型分化所必需的，这种细胞类型构成了副节的一半。在这种细胞类型的形成过程中，该基因系似乎与Wg信号通路平行发挥作用。Hh活性负责副节中的其他三种细胞类型。一些细胞类型被指定为具有Hh活性，并干扰patched的功能，这类似于成虫盘的模式形成。然而，一些模式独立于Hh对patched的拮抗作用，而是依赖于与基因系的新相互作用。最后，我们提供证据表明，在背部表皮中，骨形态发生蛋白并不介导Hh的模式形成。
