Forbes A J, Lin H, Ingham P W, Spradling A C
Molecular Embryology Laboratory, Imperial Cancer Research Fund, Developmental Biology Unit, Department of Zoology, Oxford, UK.
Development. 1996 Apr;122(4):1125-35. doi: 10.1242/dev.122.4.1125.
The hedgehog (hh) gene plays a role in regulating cell proliferation and specifying cell identity in diverse systems. We show that hh is expressed at the extreme apical end of Drosophila ovarioles in terminal filament cells and a newly identified group of associated somatic cells. Reducing or ectopically expressing hh affects somatic cells in region 2 of the germarium, 2-5 cells away from the cells in which Hh protein is detected. hh activity stimulates the proliferation of pre-follicle somatic cells, and promotes the specification of polar follicle cells. hh signaling during egg chamber assembly appears to be closely related to, or part of pathways involving the neurogenic genes.
刺猬（hh）基因在多种系统中发挥着调节细胞增殖和确定细胞身份的作用。我们发现，hh在果蝇卵巢管的顶端末端丝细胞和一组新鉴定出的相关体细胞中表达。降低或异位表达hh会影响生殖腺2区的体细胞，这些体细胞距离检测到Hh蛋白的细胞有2 - 5个细胞的距离。hh活性刺激卵泡前体细胞的增殖，并促进极性卵泡细胞的特化。卵室组装过程中的hh信号似乎与涉及神经源性基因的途径密切相关，或者是这些途径的一部分。
