胆囊收缩素A受体拮抗剂地伐西匹对鸡消化系统的作用。

The action of the cholecystokinin-A receptor antagonist, devazepide, on the digestive system of the chicken.

作者信息

Furuse M, Choi Y H, Satoh S, Okumura J

机构信息

Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.

出版信息

Experientia. 1996 Apr 15;52(4):353-6. doi: 10.1007/BF01919540.

DOI:10.1007/BF01919540

PMID:8620940

Abstract

The influence of the cholecystokinin (CCK)-A receptor antagonist, devazepide (DVZ), on the chicken digestive tract was investigated. The passage of food from the crops of birds treated with DVZ was not significantly different from that of the control. DVZ treatment did not inhibit the biliary flow stimulated by the CCK analogue, caerulein. Dispersed chicken pancreatic acini stimulated with CCK were treated with various concentrations of DVZ. At 10-5 M, DVZ completely inhibited amylase release; this concentration was much higher than those reported to have similar effects in mammals. The results suggest that the action DVZ as a CCK antagonist in the chicken is very weak.

摘要

研究了胆囊收缩素（CCK）-A受体拮抗剂地伐西匹（DVZ）对鸡消化道的影响。用DVZ处理的鸟类嗉囊中食物的通过情况与对照组无显著差异。DVZ处理并未抑制CCK类似物蛙皮素刺激的胆汁流动。用不同浓度的DVZ处理用CCK刺激的分散鸡胰腺腺泡。在10-5 M时，DVZ完全抑制淀粉酶释放；该浓度远高于在哺乳动物中报道的具有类似作用的浓度。结果表明，DVZ作为鸡体内CCK拮抗剂的作用非常弱。