Young A R, Fakouhi T D, Harrison G I, Roniker B, Swabb E A, Hawk J L
Department of Photobiology, St. John's Institute of Dermatology, University of London, St. Thomas's Hospital, UK.
J Photochem Photobiol B. 1996 Feb;32(3):165-70. doi: 10.1016/1011-1344(95)07246-2.
Lomefloxacin is a new fluoroquinolone with effective broad-spectrum antimicrobial activity. However, in common with other structurally related drugs, skin photosensitization reactions have been reported. The wavelength dependence for such photosensitization has been investigated on the previously unexposed buttock skin of 12 normal healthy human volunteers of skin types I and II. Using geometric square root of 2 dose increments, baseline 24 h minimal erythema doses were assessed at 300, 320, 330, 340, 350 and 360 nm, and with broad-band UVA. In addition, dose-response curves were constructed for erythema as measured by a reflectance device. Subjects received single daily oral doses of 400 mg lomefloxacin at specified times for 4 days. At 2 h after the final dose, new areas of buttock skin were irradiated to assess changes in minimal erythema dose and erythema dose-response. Convolution of the erythema action spectra obtained pre- and on-drug with a terrestrial solar spectrum showed that, although the UVA sensitivity on-drug was enhanced, most of the erythemally effective solar energy was still in the UVB region. An action spectrum derived for lomefloxacin skin photosensitization showed peak activity at 320 nm, the same spectral region as that for maximal absorption of the drug. There was no evidence of skin photosensitization at 300 nm.
洛美沙星是一种新型氟喹诺酮类药物，具有有效的广谱抗菌活性。然而，与其他结构相关药物一样，也有皮肤光敏反应的报道。已在12名I型和II型皮肤的正常健康人类志愿者先前未暴露的臀部皮肤上研究了这种光敏反应的波长依赖性。使用几何平方根为2的剂量递增，在300、320、330、340、350和360nm以及宽带UVA下评估基线24小时最小红斑剂量。此外，通过反射装置测量红斑，构建剂量反应曲线。受试者在特定时间每日口服400mg洛美沙星，持续4天。在最后一剂后2小时，对臀部皮肤的新区域进行照射，以评估最小红斑剂量和红斑剂量反应的变化。用药前和用药后获得的红斑作用光谱与地球太阳光谱的卷积表明，尽管用药时UVA敏感性增强，但大部分红斑有效太阳能仍在UVB区域。洛美沙星皮肤光敏反应的作用光谱在320nm处显示出峰值活性，与该药物最大吸收的光谱区域相同。在300nm处没有皮肤光敏反应的证据。
