一种由未受刺激的胎儿单核细胞释放的淋巴细胞增殖和淋巴因子产生的抑制剂。
An inhibitor of lymphocyte proliferation and lymphokine production released by unstimulated foetal monocytes.
作者信息
Wolf R L, Lominitzer R, Rabson A R
出版信息
Clin Exp Immunol. 1977 Mar;27(3):464-8.
Abstract
Supernatants obtained from 3-day cultures of cord blood monocytes inhibited normal lymphocyte activation by either PHA or in a two-way MLC. Both lymphocyte transformation and lymphokine production was significantly inhibited by these supernatants but not by those derived from adult mononuclear cell cultures. The inhibitory material produced by foetal monocytes was dialysable and was non-cytotoxic to target cells. It is postulated that this factor contributes to the depressed maternal cell-mediated immune response observed in pregnancy.
摘要
从脐血单核细胞3天培养物中获得的上清液，可抑制由PHA或双向混合淋巴细胞培养（MLC）引起的正常淋巴细胞激活。这些上清液显著抑制淋巴细胞转化和淋巴因子产生，但来自成人单核细胞培养物的上清液则无此作用。胎儿单核细胞产生的抑制物质可透析，且对靶细胞无细胞毒性。据推测，该因子导致了孕期观察到的母体细胞介导免疫反应降低。
相似文献
1
An inhibitor of lymphocyte proliferation and lymphokine production released by unstimulated foetal monocytes.一种由未受刺激的胎儿单核细胞释放的淋巴细胞增殖和淋巴因子产生的抑制剂。
Clin Exp Immunol. 1977 Mar;27(3):464-8.
2
Immune responses by cord blood cells.脐血细胞的免疫反应。
Blood Cells. 1994;20(2-3):573-85; discussion 585-6.
3
Intravenous immune globulin affects cytokine production in T lymphocytes and monocytes/macrophages.静脉注射免疫球蛋白会影响T淋巴细胞和单核细胞/巨噬细胞中细胞因子的产生。
Clin Exp Immunol. 1996 May;104 Suppl 1:10-20.
4
5
Glucocorticosteroids stimulate polyclonal immunoglobulin production by cord blood mononuclear cells.糖皮质激素刺激脐血单个核细胞产生多克隆免疫球蛋白。
J Immunol. 1984 Jul;133(1):208-12.
6
7
Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome.威斯科特-奥尔德里奇综合征中趋化性淋巴因子合成及单核白细胞趋化性异常。
J Clin Invest. 1974 Aug;54(2):486-93. doi: 10.1172/JCI107784.
8
Demonstration of a human lymphokine which renders macrophages cytotoxic.一种能使巨噬细胞产生细胞毒性的人体淋巴因子的证明。
Ann Immunol (Paris). 1977 Apr-Jun;128C(3):621-32.
9
In vitro reversal of cellular unresponsiveness induced by levamisole.左旋咪唑诱导的细胞无反应性的体外逆转
Clin Exp Immunol. 1976 Nov;26(2):295-301.
10
Monocytes control gamma/delta T-cell responses by a secreted product.单核细胞通过一种分泌产物控制γ/δ T细胞反应。
Immunology. 1995 Dec;86(4):599-605.
引用本文的文献
1
Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice.怀孕对小鼠抵抗单核细胞增生李斯特菌和弓形虫感染的影响。
Infect Immun. 1982 Dec;38(3):1164-71. doi: 10.1128/iai.38.3.1164-1171.1982.
2
Effects of monocytes from human neonates on lymphocyte transformation.人类新生儿单核细胞对淋巴细胞转化的影响。
Clin Exp Immunol. 1979 Jun;36(3):511-20.
3
Maternal smoking and cord blood immunity function.孕妇吸烟与脐带血免疫功能
Clin Exp Immunol. 1979 May;36(2):256-9.
4
Immunologic and genetic factors influencing reproduction. A review.影响生殖的免疫和遗传因素。综述。
Am J Pathol. 1979 May;95(2):465-570.
5
Suppression of B lymphocyte differentiation by newborn T lymphocytes with an Fc receptor for IgM.具有IgM Fc受体的新生T淋巴细胞对B淋巴细胞分化的抑制作用。
Clin Exp Immunol. 1978 Dec;34(3):374-8.
6
Effects of human alpha-foetoprotein on human B and T lymphocyte proliferation in vitro.人甲胎蛋白对人B淋巴细胞和T淋巴细胞体外增殖的影响。
Clin Exp Immunol. 1978 Aug;33(2):347-56.
本文引用的文献
1
2
Induction of immunity and tolerance in vitro in the absence of phagocytic cells.在无吞噬细胞的情况下体外诱导免疫和耐受。
Nature. 1970 Feb 21;225(5234):731-2. doi: 10.1038/225731a0.
3
A factor in maternal plasma during pregnancy that suppresses the reactivity of mixed leukocyte cultures.孕期母体血浆中一种抑制混合白细胞培养反应性的因子。
J Immunol. 1971 Nov;107(5):1296-301.
4
Immunological responses in pregnancy and survival of fetal homograft.妊娠中的免疫反应与胎儿同种移植物的存活
Br Med J. 1972 Jul 15;3(5819):150-2. doi: 10.1136/bmj.3.5819.150.
5
Restimulation of antibody synthesis by antigen in cultures of lymphocytes.
Nature. 1968 Jul 20;219(5151):297-8. doi: 10.1038/219297a0.
6
Macrophage regulation of DNA synthesis in lymphoid cells: effects of a soluble factor from macrophages.巨噬细胞对淋巴细胞中DNA合成的调节：巨噬细胞可溶性因子的作用。
Cell Immunol. 1973 Oct;9(1):142-56. doi: 10.1016/0008-8749(73)90175-5.
7
Investigation of the structure of yeast tRNAphe by nuclear magnetic resonance: paramagnetic rare earth ion probes of structure.通过核磁共振研究酵母苯丙氨酸转运核糖核酸的结构：结构的顺磁性稀土离子探针
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4237-40. doi: 10.1073/pnas.71.10.4237.
8
9
Regulation of lymphocyte responses in vitro. I. Regulatory effect of macrophages and thymus-dependent (T) cells on the response of thymus-independent (B) lymphocytes to endotoxin.体外淋巴细胞反应的调节。I. 巨噬细胞和胸腺依赖性（T）细胞对胸腺非依赖性（B）淋巴细胞对内毒素反应的调节作用。
J Exp Med. 1972 Oct 1;136(4):956-61. doi: 10.1084/jem.136.4.956.
10
Lymphocytes from human newborns abrogate mitosis of their mother's lymphocytes.人类新生儿的淋巴细胞会抑制其母亲淋巴细胞的有丝分裂。
Nature. 1974 May 10;249(453):161-2. doi: 10.1038/249161a0.
Zotero 插件