体外淋巴细胞反应的调节。I. 巨噬细胞和胸腺依赖性（T）细胞对胸腺非依赖性（B）淋巴细胞对内毒素反应的调节作用。
Regulation of lymphocyte responses in vitro. I. Regulatory effect of macrophages and thymus-dependent (T) cells on the response of thymus-independent (B) lymphocytes to endotoxin.
作者信息
Yoshinaga M, Yoshinaga A, Waksman B H
出版信息
J Exp Med. 1972 Oct 1;136(4):956-61. doi: 10.1084/jem.136.4.956.
Abstract
DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T-deprived spleen. We conclude that two mechanisms of suppression are at work: a direct effect of macrophages and a macrophage-dependent "suppressor T cell" effect.
摘要
如果首先从细胞悬液中去除贴壁细胞，正常大鼠脾细胞对内毒素反应的DNA合成会显著增加。向培养物中添加少量纯化的巨噬细胞可将反应恢复到较低水平。去除T细胞的细胞表现出的这些效应程度要小得多。大量巨噬细胞会完全抑制正常和去除T细胞的脾细胞的反应。我们得出结论，有两种抑制机制在起作用：巨噬细胞的直接作用和巨噬细胞依赖性“抑制性T细胞”作用。
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