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体外淋巴细胞反应的调节。I. 巨噬细胞和胸腺依赖性（T）细胞对胸腺非依赖性（B）淋巴细胞对内毒素反应的调节作用。

Regulation of lymphocyte responses in vitro. I. Regulatory effect of macrophages and thymus-dependent (T) cells on the response of thymus-independent (B) lymphocytes to endotoxin.

作者信息

Yoshinaga M, Yoshinaga A, Waksman B H

出版信息

J Exp Med. 1972 Oct 1;136(4):956-61. doi: 10.1084/jem.136.4.956.

DOI:10.1084/jem.136.4.956
PMID:4560346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139268/
Abstract

DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T-deprived spleen. We conclude that two mechanisms of suppression are at work: a direct effect of macrophages and a macrophage-dependent "suppressor T cell" effect.

摘要

如果首先从细胞悬液中去除贴壁细胞，正常大鼠脾细胞对内毒素反应的DNA合成会显著增加。向培养物中添加少量纯化的巨噬细胞可将反应恢复到较低水平。去除T细胞的细胞表现出的这些效应程度要小得多。大量巨噬细胞会完全抑制正常和去除T细胞的脾细胞的反应。我们得出结论，有两种抑制机制在起作用：巨噬细胞的直接作用和巨噬细胞依赖性“抑制性T细胞”作用。

相似文献

1
Regulation of lymphocyte responses in vitro. I. Regulatory effect of macrophages and thymus-dependent (T) cells on the response of thymus-independent (B) lymphocytes to endotoxin.体外淋巴细胞反应的调节。I. 巨噬细胞和胸腺依赖性（T）细胞对胸腺非依赖性（B）淋巴细胞对内毒素反应的调节作用。
J Exp Med. 1972 Oct 1;136(4):956-61. doi: 10.1084/jem.136.4.956.
2
Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T 6 T 6 thymus grafts.内毒素对B淋巴细胞的刺激。无胸腺小鼠的反应以及携带T6T6胸腺移植的小鼠中分裂细胞的核型分析。
J Immunol. 1972 Apr;108(4):1088-91.
3
Production by murine spleen cells of an activity stimulating the PHA-responsiveness of thymus lymphocytes.小鼠脾细胞产生一种刺激胸腺淋巴细胞对PHA反应性的活性物质。
Cell Immunol. 1975 Jun;17(2):495-504. doi: 10.1016/s0008-8749(75)80053-0.
4
The response of rabbit lymphocytes to mitogens and alloantigens: evidence for T cell heterogeneity.兔淋巴细胞对有丝分裂原和同种异体抗原的反应：T细胞异质性的证据。
J Immunol. 1974 Dec;113(6):1780-92.
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Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. I. Target cells and possible mode of action.体外多聚阴离子对小鼠淋巴细胞DNA合成的刺激作用。I. 靶细胞及可能的作用方式。
Eur J Immunol. 1973 Aug;3(8):488-93. doi: 10.1002/eji.1830030807.
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Activation of B lymphocytes by concanavalin A in the presence of humoral factors released by T cells.在T细胞释放的体液因子存在的情况下，伴刀豆球蛋白A对B淋巴细胞的激活作用。
Transplant Proc. 1972 Sep;4(3):321-4.
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Regulation of lymphocyte responses in vitro. 3. Inhibition by adherent cells of the T-lymphocyte response to phytohemagglutinin.体外淋巴细胞反应的调节。3. 贴壁细胞对T淋巴细胞对植物血凝素反应的抑制作用。
J Immunol. 1973 Mar;110(3):835-9.
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Thymus origin of lymphocytes reacting and stimulating reaction in mixed lymphocyte cultures--studies in the rat.混合淋巴细胞培养中发生反应并刺激反应的淋巴细胞的胸腺起源——大鼠研究
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In vitro responses of rat lymphocytes following adult thymectomy. II. Increased inhibition by splenic adherent cells of responses to phytohemagglutinin.成年大鼠胸腺切除术后大鼠淋巴细胞的体外反应。II. 脾黏附细胞对植物血凝素反应的抑制作用增强。
Cell Immunol. 1973 Oct;9(1):25-31. doi: 10.1016/0008-8749(73)90164-0.
10
In vitro responses of rat lymphocytes following adult thymectomy. I. Rapid decrease and recovery of responses to mitogens and hemiallogeneic cells.成年大鼠胸腺切除术后大鼠淋巴细胞的体外反应。I. 对有丝分裂原和半同种异体细胞反应的快速下降和恢复。
J Immunol. 1972 Nov;109(5):1046-51.

引用本文的文献

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Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm.特殊调节性T细胞综述：换个名字的玫瑰：从抑制性T细胞到调节性T细胞，从认可到过度热情。
Immunology. 2008 Jan;123(1):20-7. doi: 10.1111/j.1365-2567.2007.02779.x.
2
Functional absence of a B cell subpopulation in ageing New Zealand mice.衰老的新西兰小鼠中一个B细胞亚群的功能缺失。
Clin Exp Immunol. 1980 May;40(2):365-72.
3
Activation of human T and non-T lymphocytes by sepharose-bound concanavalin A and the differential effect of macrophages.琼脂糖结合的伴刀豆球蛋白A对人T淋巴细胞和非T淋巴细胞的激活作用以及巨噬细胞的差异效应。
Immunology. 1981 Oct;44(2):215-22.
4
Kinetics of the reactivity of subpopulations of spleen cells of mice bearing virus-induced mammary tumors to syngeneic antigenic extracts in vitro. Supportive and suppressive effects of macrophages.携带病毒诱导乳腺肿瘤的小鼠脾细胞亚群在体外对同基因抗原提取物反应性的动力学。巨噬细胞的支持和抑制作用。
Cancer Immunol Immunother. 1982;13(2):98-104. doi: 10.1007/BF00205308.
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[Humoral factors in the regulation of cell proliferation in haematopoiesis. I. Granulopoiesis and lymphopoiesis (author's transl)].[造血过程中细胞增殖调节的体液因素。I. 粒细胞生成和淋巴细胞生成（作者译）]
Klin Wochenschr. 1980 Oct 15;58(20):1117-33. doi: 10.1007/BF01477234.
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The response of synovial fluid lymphocytes to T and B stimulants in vitro.体外滑膜液淋巴细胞对T和B刺激剂的反应。
Immunology. 1973 Nov;25(5):905-8.
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Modulation of cell proliferation by macrophages: a possible function apart from cytotoxic tumour rejection.巨噬细胞对细胞增殖的调节：除细胞毒性肿瘤排斥外的一种可能功能。
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Nutrition and immunological responsiveness. T-cell function in the offspring of lipotrope and protein-deficient rats.营养与免疫反应性。低脂血症和蛋白质缺乏大鼠后代的T细胞功能。
Immunology. 1974 Mar;26(3):489-95.
9
Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses.胸腺来源淋巴细胞在抗体应答中的选择性作用。I. 载体致敏T细胞对半抗原特异性IgM和IgG抗体应答的差异抑制作用。
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Involvement of inflammatory leukocytes in hepatic induction of T-kininogen in rat.炎症性白细胞在大鼠肝脏诱导T-激肽原中的作用。
Inflammation. 1987 Sep;11(3):345-52. doi: 10.1007/BF00915838.

本文引用的文献

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Alterations of macrophage functions by mediators from lymphocytes.淋巴细胞分泌的介质对巨噬细胞功能的影响。
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Lymphocyte reactivity in vitro. I. Cellular reconstitution of purified lymphocyte response.淋巴细胞的体外反应性。I. 纯化淋巴细胞反应的细胞重建。
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Activation of normal rabbit macrophage monolayers by supernatants of antigen-stimulated lymphocytes.抗原刺激淋巴细胞的上清液对正常兔巨噬细胞单层的激活作用。
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Immune response restoration with macrophage culture supernatants.巨噬细胞培养上清液恢复免疫反应。
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Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).T淋巴细胞对丝裂原反应的增强作用。II. 增强介质的细胞来源。
J Exp Med. 1972 Jul 1;136(1):143-55. doi: 10.1084/jem.136.1.143.
6
Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.T淋巴细胞对丝裂原反应的增强作用。I. 反应细胞。
J Exp Med. 1972 Jul 1;136(1):128-42. doi: 10.1084/jem.136.1.128.
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Effect of antigenic competition on antigen-sensitive cells and on adoptively transferred immunocompetent cells.抗原竞争对抗原敏感细胞及过继转移的免疫活性细胞的影响。
Cell Immunol. 1970 May;1(1):110-21. doi: 10.1016/0008-8749(70)90064-x.
8
A study of mixed cell interactions between sensitized and allogeneic mouse spleen cells in vitro using the hemolytic plaque assay.一项利用溶血空斑试验对致敏小鼠脾细胞与同种异体小鼠脾细胞之间的混合细胞相互作用进行的体外研究。
J Immunol. 1971 Mar;106(3):619-28.
9
The selective inhibition of macrophage phagocytic receptors by anti-membrane antibodies.抗膜抗体对巨噬细胞吞噬受体的选择性抑制作用。
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10
When allogeneic mouse spleen cells are mixed in vitro the T-cells secrete a product which guides the maturation of B-cells.当同种异体小鼠脾细胞在体外混合时，T细胞会分泌一种引导B细胞成熟的产物。
Scand J Immunol. 1972;1(1):89-98. doi: 10.1111/j.1365-3083.1972.tb03738.x.