Anderson A W, Zhong J, Petroff O A, Szafer A, Ransom B R, Prichard J W, Gore J C
Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Magn Reson Med. 1996 Feb;35(2):162-7. doi: 10.1002/mrm.1910350206.
The apparent diffusion coefficient (ADC) of the rat optic nerve was measured in vitro, using magnetic resonance imaging, to determine the effects of changes in cellular volume fraction on the diffusion of tissue water. Nerve ADC was determined under conditions of cell membrane depolarization and (i) increased intracellular volume, (ii) decreased intracellular volume, and (iii) negligible volume change. Depolarization alone had little affect on ADC, whereas volume changes produced strong, reversible effects. Increased cell volume decreased ADC and vice versa. These results are consistent with the view that changes in the extracellular space are the major source of ADC changes in brain tissue.
利用磁共振成像在体外测量大鼠视神经的表观扩散系数（ADC），以确定细胞体积分数变化对组织水扩散的影响。在细胞膜去极化以及（i）细胞内体积增加、（ii）细胞内体积减少和（iii）体积变化可忽略不计的条件下测定神经ADC。单独去极化对ADC影响很小，而体积变化产生强烈的、可逆的影响。细胞体积增加会降低ADC，反之亦然。这些结果与细胞外间隙变化是脑组织ADC变化的主要来源这一观点一致。
