Boon A, Lodder J, Cheriex E, Kessels F
Department of Neurology, St-Anna Hospital, Geldrop, Netherlands.
Stroke. 1996 May;27(5):847-51. doi: 10.1161/01.str.27.5.847.
We sought to establish the possible role of calcification of the aortic valve with or without stenosis as a risk factor for stroke.
Occurrences of stroke, stroke subtypes, and concomitant cardiovascular risk factors were prospectively analyzed in 300 patients with echocardiographic evidence of aortic valve calcification, 515 patients with calcified aortic valve stenosis, and 562 control subjects.
Twenty-four patients with aortic valve calcification, 24 patients with calcified aortic valve stenosis, and 27 control subjects had a stroke during follow-up. Using Cox proportional hazards models, we found that strokes were not significantly associated with aortic valve calcification with or without stenosis, but hypertension and any carotid stenosis were associated. On multiple logistic regression analysis, we did not find any association between one of the two valve lesions and indirect possible indications of cardiogenic embolism such as territorial as opposed to small deep brain infarcts or the presence of silent brain infarcts.
Aortic valve calcification with or without stenosis is not a risk factor for stroke.
我们试图确定伴或不伴狭窄的主动脉瓣钙化作为卒中危险因素的可能作用。
对300例有主动脉瓣钙化超声心动图证据的患者、515例有钙化性主动脉瓣狭窄的患者和562例对照者的卒中发生情况、卒中亚型及伴随的心血管危险因素进行前瞻性分析。
24例主动脉瓣钙化患者、24例钙化性主动脉瓣狭窄患者和27例对照者在随访期间发生了卒中。使用Cox比例风险模型，我们发现卒中与伴或不伴狭窄的主动脉瓣钙化无显著关联，但与高血压和任何颈动脉狭窄有关。在多因素逻辑回归分析中，我们未发现两种瓣膜病变之一与心源性栓塞的间接可能指征（如与小的深部脑梗死相对的区域性梗死或无症状脑梗死的存在）之间存在任何关联。
伴或不伴狭窄的主动脉瓣钙化不是卒中的危险因素。
