Technicon Immuno 1游离甲状腺素检测法的评估

Evaluation of the Technicon Immuno 1 free thyroxine assay.

作者信息

Bock J L, Morris D, Cheng J, Ehresman D

机构信息

Department of Pathology, State University of New York at Stony Brook 11794-7300, USA.

出版信息

Am J Clin Pathol. 1996 May;105(5):583-8. doi: 10.1093/ajcp/105.5.583.

DOI:10.1093/ajcp/105.5.583

PMID:8623767

Abstract

The Technicon Immuno 1 free thyroxine (fT4) assay, a modified two-step procedure that is fully automated on a random access analyzer, was evaluated-at two clinical sites. The method had excellent precision and correlated well overall with three other estimates of free thyroxine: free thyroxine index (FTI) measured on the Immuno 1; the Abbott IMx fT4 assay (Abbott Park, IL); and the Clinical Assays two-step manual fT4 assay. Using a combination of thyrotropin and FTI assay results as a "gold standard" for defining thyroid status, the Immuno 1 fT4 method had a sensitivity of 100% and specificity of 98.3% for hyperthyroidism, versus 93.8% and 99.3%, respectively, for hypothyroidism. In conclusion, the Immuno 1 fT4 assay is useful in screening for thyroid disease.

摘要

Technicon Immuno 1游离甲状腺素（fT4）检测法是一种改良的两步法，可在随机存取分析仪上完全自动化，在两个临床地点进行了评估。该方法具有出色的精密度，并且与其他三种游离甲状腺素的估计值总体相关性良好：在Immuno 1上测量的游离甲状腺素指数（FTI）；雅培IMx fT4检测法（伊利诺伊州雅培公园）；以及临床检测两步法手工fT4检测法。使用促甲状腺激素和FTI检测结果的组合作为定义甲状腺状态的“金标准”，Immuno 1 fT4方法对甲状腺功能亢进的敏感性为100%，特异性为98.3%，而对甲状腺功能减退的敏感性和特异性分别为93.8%和99.3%。总之，Immuno 1 fT4检测法在甲状腺疾病筛查中很有用。