Harel Z, Biro F M, Kottenhahn R K, Rosenthal S L
Division of Adolescent Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Am J Obstet Gynecol. 1996 Apr;174(4):1335-8. doi: 10.1016/s0002-9378(96)70681-6.
The purpose of the study was to examine whether dietary supplementation with omega-3 fatty acids can relieve symptoms of dysmenorrhea in adolescents.
Forty-two adolescents with dysmenorrhea were randomly allocated to two groups. In the first group 21 girls received fish oil (1080 mg icosapentaenoic acid, 720 mg docosahexaenoic acid, and 1.5 mg vitamin E) daily for 2 months followed by a placebo for an additional 2 months. In the second group 21 girls received placebo for the first 2 months, followed by fish oil for 2 more months. The Cox Menstrual Symptom Scale was used to assess response to treatment.
There were no significant differences in the Cox Menstrual Symptom Scale between the two groups at baseline after 2 months of placebo administration. After 2 months of treatment with fish oil there was a marked reduction in the Cox Menstrual Symptom Scale from a baseline mean value of 69.9 to 44.0 (p < 0.0004).
This study suggests that dietary supplementation with omega-3 fatty acids has a beneficial effect on symptoms of dysmenorrhea in adolescents.
本研究旨在探讨补充ω-3脂肪酸饮食是否能缓解青少年痛经症状。
42名痛经青少年被随机分为两组。第一组21名女孩每天服用鱼油（1080毫克二十碳五烯酸、720毫克二十二碳六烯酸和1.5毫克维生素E），持续2个月，随后再服用2个月安慰剂。第二组21名女孩前2个月服用安慰剂，随后再服用2个月鱼油。采用考克斯月经症状量表评估治疗反应。
在服用安慰剂2个月后的基线期，两组在考克斯月经症状量表上无显著差异。服用鱼油治疗2个月后，考克斯月经症状量表从基线平均值69.9显著降至44.0（p<0.0004）。
本研究表明，补充ω-3脂肪酸饮食对青少年痛经症状有有益影响。
